Human TM9SF4 activation kit by CRISPRa

CAT#: GA106580

TM9SF4 CRISPRa kit - CRISPR gene activation of human transmembrane 9 superfamily member 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TM9SF4
• Locus ID: 9777
• Kit Components:

  GA106580G1, TM9SF4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106580G2, TM9SF4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106580G3, TM9SF4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014742, NM_001363731
• UniProt ID: Q92544
• Synonyms: dJ836N17.2
• Summary: Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).[UniProtKB/Swiss-Prot Function]