Human GCAP3 (GUCA1C) activation kit by CRISPRa

CAT#: GA106446

GUCA1C CRISPRa kit - CRISPR gene activation of human guanylate cyclase activator 1C

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: GUCA1C
• Locus ID: 9626
• Kit Components:

  GA106446G1, GCAP3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106446G2, GCAP3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106446G3, GCAP3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005459, NM_001363884
• UniProt ID: O95843
• Synonyms: GCAP3
• Summary: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.[UniProtKB/Swiss-Prot Function]