Human STXBP5L activation kit by CRISPRa

CAT#: GA106361

STXBP5L CRISPRa kit - CRISPR gene activation of human syntaxin binding protein 5 like

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: STXBP5L
• Locus ID: 9515
• Kit Components:

  GA106361G1, STXBP5L gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106361G2, STXBP5L gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106361G3, STXBP5L gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001308330, NM_014980, NM_001348343, NM_001348344, NM_001348345, NR_145516, NR_145517
• UniProt ID: Q9Y2K9
• Synonyms: LLGL4
• Summary: The protein encoded by this gene is similar to syntaxin-binding protein 5 and contains ten N-terminal WD40 repeats, four variable region WD40 repeats, and a C-terminal R-SNARE domain. Studies of the orthologous proteins in mouse and rat have shown that the encoded protein may inhibit exocytosis in neurosecretory cells, and may negatively regulate the secretion of insulin. A missense variant in this gene is likely the cause of an infantile-onset neurodegenerative disorder diagnosed in two siblings of consanguineous parents. [provided by RefSeq, Jan 2017]