Human Retinal protein 4 (UNC119) activation kit by CRISPRa

CAT#: GA106053

UNC119 CRISPRa kit - CRISPR gene activation of human unc-119 lipid binding chaperone

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: UNC119
• Locus ID: 9094
• Kit Components:

  GA106053G1, Retinal protein 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106053G2, Retinal protein 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106053G3, Retinal protein 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001330166, NM_005148, NM_054035
• UniProt ID: Q13432
• Synonyms: HRG4; IMD13; POC7; POC7A
• Summary: This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]