Human CBX4 activation kit by CRISPRa

CAT#: GA105649

CBX4 CRISPRa kit - CRISPR gene activation of human chromobox 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: CBX4
• Locus ID: 8535
• Kit Components:

  GA105649G1, CBX4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105649G2, CBX4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105649G3, CBX4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003655
• UniProt ID: O00257
• Synonyms: NBP16; PC2
• Summary: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).[UniProtKB/Swiss-Prot Function]