Human LAGE3 activation kit by CRISPRa

CAT#: GA105461

LAGE3 CRISPRa kit - CRISPR gene activation of human L antigen family member 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: LAGE3
• Locus ID: 8270
• Kit Components:

  GA105461G1, LAGE3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105461G2, LAGE3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105461G3, LAGE3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006014
• UniProt ID: Q14657
• Synonyms: CVG5; DXS9879E; DXS9951E; ESO3; ITBA2; Pcc1
• Summary: This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008]