Human ZFX activation kit by CRISPRa

CAT#: GA105192

ZFX CRISPRa kit - CRISPR gene activation of human zinc finger protein X-linked

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ZFX
• Locus ID: 7543
• Kit Components:

  GA105192G1, ZFX gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105192G2, ZFX gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105192G3, ZFX gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001178084, NM_001178085, NM_001178086, NM_001178095, NM_003410, NM_001330327
• UniProt ID: P17010
• Synonyms: ZNF926
• Summary: This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]