Human WFS1 activation kit by CRISPRa

CAT#: GA105144

WFS1 CRISPRa kit - CRISPR gene activation of human wolframin ER transmembrane glycoprotein

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: WFS1
• Locus ID: 7466
• Kit Components:

  GA105144G1, WFS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105144G2, WFS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105144G3, WFS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145853, NM_006005
• UniProt ID: O76024
• Synonyms: CTRCT41; WFRS; WFS; WFSL
• Summary: This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]