Human Thymidine Kinase 1 (TK1) activation kit by CRISPRa

CAT#: GA104885

TK1 CRISPRa kit - CRISPR gene activation of human thymidine kinase 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TK1
• Locus ID: 7083
• Kit Components:

  GA104885G1, Thymidine Kinase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104885G2, Thymidine Kinase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104885G3, Thymidine Kinase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003258, NM_001346663, NM_001363848
• UniProt ID: P04183
• Synonyms: TK2
• Summary: The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]