Human TBCE activation kit by CRISPRa

CAT#: GA104761

TBCE CRISPRa kit - CRISPR gene activation of human tubulin folding cofactor E

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TBCE
• Locus ID: 6905
• Kit Components:

  GA104761G1, TBCE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104761G2, TBCE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104761G3, TBCE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001079515, NM_001287801, NM_001287802, NM_003193
• UniProt ID: Q15813
• Synonyms: HRD; KCS; KCS1; pac2
• Summary: Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]