Human PPM1G activation kit by CRISPRa

CAT#: GA103702

PPM1G CRISPRa kit - CRISPR gene activation of human protein phosphatase, Mg2+/Mn2+ dependent 1G

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PPM1G
• Locus ID: 5496
• Kit Components:

  GA103702G1, PPM1G gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103702G2, PPM1G gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103702G3, PPM1G gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002707, NM_177983
• UniProt ID: O15355
• Synonyms: MGC1675; MGC2870; PP2CG; PP2CGAMMA; PPP2CG
• Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]