Human PI3 activation kit by CRISPRa

CAT#: GA103535

PI3 CRISPRa kit - CRISPR gene activation of human peptidase inhibitor 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PI3
• Locus ID: 5266
• Kit Components:

  GA103535G1, PI3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103535G2, PI3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103535G3, PI3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002638
• UniProt ID: P19957
• Synonyms: cementoin; ESI; SKALP; WAP3; WFDC14
• Summary: This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]