Human PDE4 (PDE4B) activation kit by CRISPRa

CAT#: GA103439

PDE4B CRISPRa kit - CRISPR gene activation of human phosphodiesterase 4B

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PDE4B
• Locus ID: 5142
• Kit Components:

  GA103439G1, PDE4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103439G2, PDE4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103439G3, PDE4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037339, NM_001037340, NM_001037341, NM_001297440, NM_001297441, NM_001297442, NM_002600
• UniProt ID: Q07343
• Synonyms: DPDE4; PDEIVB
• Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]