Human MMP15 activation kit by CRISPRa

CAT#: GA102944

MMP15 CRISPRa kit - CRISPR gene activation of human matrix metallopeptidase 15

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MMP15
• Locus ID: 4324
• Kit Components:

  GA102944G1, MMP15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102944G2, MMP15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102944G3, MMP15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002428
• UniProt ID: P51511
• Synonyms: MT2-MMP; MTMMP2; SMCP-2
• Summary: This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]