Human LMO2 activation kit by CRISPRa

CAT#: GA102714

LMO2 CRISPRa kit - CRISPR gene activation of human LIM domain only 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: LMO2
• Locus ID: 4005
• Kit Components:

  GA102714G1, LMO2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102714G2, LMO2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102714G3, LMO2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142315, NM_001142316, NM_005574
• UniProt ID: P25791
• Synonyms: RBTN2; RBTNL1; RHOM2; TTG2
• Summary: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]