Human GABRG3 activation kit by CRISPRa

CAT#: GA101710

GABRG3 CRISPRa kit - CRISPR gene activation of human gamma-aminobutyric acid type A receptor gamma3 subunit

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: GABRG3
• Locus ID: 2567
• Kit Components:

  GA101710G1, GABRG3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101710G2, GABRG3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101710G3, GABRG3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270873, NM_033223
• UniProt ID: Q99928
• Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]