Human GABPA activation kit by CRISPRa

CAT#: GA101695

GABPA CRISPRa kit - CRISPR gene activation of human GA binding protein transcription factor subunit alpha

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: GABPA
• Locus ID: 2551
• Kit Components:

  GA101695G1, GABPA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101695G2, GABPA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101695G3, GABPA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001197297, NM_002040
• UniProt ID: Q06546
• Synonyms: E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A; RCH04A07
• Summary: This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]