Human Flt3 ligand (FLT3LG) activation kit by CRISPRa

CAT#: GA101631

FLT3LG CRISPRa kit - CRISPR gene activation of human fms related tyrosine kinase 3 ligand

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: FLT3LG
• Locus ID: 2323
• Kit Components:

  GA101631G1, Flt3 ligand gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101631G2, Flt3 ligand gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101631G3, Flt3 ligand gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001204502, NM_001204503, NM_001278637, NM_001278638, NM_001459
• UniProt ID: P49771
• Synonyms: FL; FLT3L
• Summary: Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]