Human Dishevelled 2 (DVL2) activation kit by CRISPRa

CAT#: GA101304

DVL2 CRISPRa kit - CRISPR gene activation of human dishevelled segment polarity protein 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: DVL2
• Locus ID: 1856
• Kit Components:

  GA101304G1, Dishevelled 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101304G2, Dishevelled 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101304G3, Dishevelled 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004422
• UniProt ID: O14641
• Synonyms: dishevelled, dsh homolog 2 (Drosophila); dishevelled 2; dishevelled 2 (homologous to Drosophila dsh); DSH homolog 2; segment polarity protein dishevelled homolog DVL-2
• Summary: This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]