Human IKK alpha (CHUK) activation kit by CRISPRa

CAT#: GA100824

CHUK CRISPRa kit - CRISPR gene activation of human component of inhibitor of nuclear factor kappa B kinase complex

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: CHUK
• Locus ID: 1147
• Kit Components:

  GA100824G1, IKK alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100824G2, IKK alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100824G3, IKK alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278, NM_001320928
• UniProt ID: O15111
• Synonyms: IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
• Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]