Human Carbonic Anhydrase XI (CA11) activation kit by CRISPRa

CAT#: GA100536

CA11 CRISPRa kit - CRISPR gene activation of human carbonic anhydrase 11

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: CA11
• Locus ID: 770
• Kit Components:

  GA100536G1, Carbonic Anhydrase XI gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100536G2, Carbonic Anhydrase XI gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100536G3, Carbonic Anhydrase XI gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001217, NR_136241
• UniProt ID: O75493
• Synonyms: CARPX1
• Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]