Human Angiopoietin 1 (ANGPT1) activation kit by CRISPRa

CAT#: GA100197

ANGPT1 CRISPRa kit - CRISPR gene activation of human angiopoietin 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ANGPT1
• Locus ID: 284
• Kit Components:

  GA100197G1, Angiopoietin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100197G2, Angiopoietin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100197G3, Angiopoietin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001146, NM_001199859, NM_001314051, NM_139290
• UniProt ID: Q15389
• Synonyms: AGP1; AGPT; ANG1
• Summary: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema. [provided by RefSeq, Aug 2020]