Human ACADM activation kit by CRISPRa

CAT#: GA100026

ACADM CRISPRa kit - CRISPR gene activation of human acyl-CoA dehydrogenase medium chain

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ACADM
• Locus ID: 34
• Kit Components:

  GA100026G1, ACADM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100026G2, ACADM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100026G3, ACADM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000016, NM_001127328, NM_001286042, NM_001286043, NM_001286044, NR_022013
• UniProt ID: P11310
• Synonyms: ACAD1; MCAD; MCADH
• Summary: This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]