Pak7 (NM_001107781) Rat Tagged ORF Clone Lentiviral Particle

CAT#: RR203432L3V

Lenti ORF particles, Pak7 (Myc-DDK-tagged ORF) - Rat p21 (CDKN1A)-activated kinase 7 (Pak7), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Rat Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: Pak7
• Synonyms: PAK-5; PAK-7; Pak5
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_001107781
• ORF Size: 2154 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RR203432).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001107781.1, NP_001101251.1
• RefSeq Size: 4040 bp
• RefSeq ORF: 2157 bp
• Locus ID: 311450
• UniProt ID: D4A280
• Cytogenetics: 3q36
• Gene Summary: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity).[UniProtKB/Swiss-Prot Function]