TTC3 (NM_001001894) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC221585L1V

Lenti ORF particles, TTC3 (Myc-DDK tagged) - Human tetratricopeptide repeat domain 3 (TTC3), transcript variant 2, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: TTC3
• Synonyms: DCRR1; RNF105; TPRDIII
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_001001894
• ORF Size: 6075 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC221585).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001001894.1
• RefSeq Size: 7730 bp
• RefSeq ORF: 6078 bp
• Locus ID: 7267
• UniProt ID: P53804
• Cytogenetics: 21q22.13
• Protein Families: Druggable Genome
• MW: 229.7 kDa
• Gene Summary: E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.[UniProtKB/Swiss-Prot Function]