WAVE 1 (WASF1) (NM_003931) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC216977L2V

Lenti ORF particles, WASF1 (mGFP-tagged) - Human WAS protein family, member 1 (WASF1), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: WAVE 1
• Synonyms: NEDALVS; SCAR1; WAVE; WAVE1
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_003931
• ORF Size: 1677 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC216977).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003931.2
• RefSeq Size: 3230 bp
• RefSeq ORF: 1680 bp
• Locus ID: 8936
• UniProt ID: Q92558
• Cytogenetics: 6q21
• Domains: WH2
• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton
• MW: 61.5 kDa
• Gene Summary: The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]