Ribonuclease H2, subunit A (RNASEH2A) (NM_006397) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC204032L1V

Lenti ORF particles, RNASEH2A (Myc-DDK tagged) - Human ribonuclease H2, subunit A (RNASEH2A), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: Ribonuclease H2, subunit A
• Synonyms: AGS4; JUNB; RNASEHI; RNHIA; RNHL; THSD8
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_006397
• ORF Size: 897 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC204032).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_006397.2
• RefSeq Size: 1148 bp
• RefSeq ORF: 900 bp
• Locus ID: 10535
• UniProt ID: O75792
• Cytogenetics: 19p13.13
• Domains: RNase_HII
• Protein Pathways: DNA replication
• MW: 33.4 kDa
• Gene Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]