Dlg4 (NM_007864) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR227405L3V

Lenti ORF particles, Dlg4 (Myc-DDK-tagged) - Mouse discs, large homolog 4 (Drosophila) (Dlg4), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: Dlg4
• Synonyms: Dlgh4; PSD-95; PSD95; SAP90; SAP90A
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_007864
• ORF Size: 2172 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR227405).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_007864.3, NP_031890.1
• RefSeq Size: 3339 bp
• RefSeq ORF: 2175 bp
• Locus ID: 13385
• UniProt ID: Q62108
• Cytogenetics: 11 B3
• Gene Summary: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable).[UniProtKB/Swiss-Prot Function]