Drosha (NM_001130149) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR227001L4V
- LentiORF®
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Lenti ORF particles, Drosha (GFP-tagged) - Mouse drosha, ribonuclease type III (Drosha), transcript variant 1, 200ul, >10^7 TU/mL
Lentiviral Particles: DDK w/ Puro
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Specifications
Product Data | |
Type | Mouse Tagged ORF Clone Lentiviral Particle |
Tag | mGFP |
Symbol | Drosha |
Synonyms | 1110013A17Rik; AI874853; Etohi2; Rn3; Rnasen |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_001130149 |
ORF Size | 4119 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR227001).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001130149.1, NP_001123621.1 |
RefSeq Size | 4584 bp |
RefSeq ORF | 4122 bp |
Locus ID | 14000 |
UniProt ID | Q5HZJ0 |
Cytogenetics | 15 A1 |
Gene Summary | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.[UniProtKB/Swiss-Prot Function] |
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