Il31ra (NM_139299) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR216199L3V

Lenti ORF particles, Il31ra (Myc-DDK-tagged) - Mouse interleukin 31 receptor A (Il31ra), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: Il31ra
• Synonyms: CRL3; GLM-R; Glmr; GPL; NR10
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_139299
• ORF Size: 2148 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR216199).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_139299.2, NP_647460.2
• RefSeq Size: 3680 bp
• RefSeq ORF: 2151 bp
• Locus ID: 218624
• UniProt ID: Q8K5B1
• Cytogenetics: 13 D2.2
• Gene Summary: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091).[UniProtKB/Swiss-Prot Function]