Lrp6 (NM_008514) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR212053L4V
- LentiORF®
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Lenti ORF particles, Lrp6 (GFP-tagged) - Mouse low density lipoprotein receptor-related protein 6 (Lrp6), 200ul, >10^7 TU/mL
Lentiviral Particles: DDK w/ Puro
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Specifications
Product Data | |
Type | Mouse Tagged ORF Clone Lentiviral Particle |
Tag | mGFP |
Symbol | Lrp6 |
Synonyms | C030016K15Rik; Cd; Gw; ska26; ska |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_008514 |
ORF Size | 4839 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR212053).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_008514.4, NP_032540.2 |
RefSeq Size | 9368 bp |
RefSeq ORF | 4842 bp |
Locus ID | 16974 |
UniProt ID | O88572 |
Cytogenetics | 6 65.37 cM |
Gene Summary | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).[UniProtKB/Swiss-Prot Function] |
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