DMXL2 (NM_001174117) Human Untagged Clone

CAT#: SC329387

DMXL2 (untagged)-Human Dmx-like 2 (DMXL2) transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DMXL2
• Synonyms: DEE81; DFNA71; EIEE81; PEPNS; RC3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001174117, the custom clone sequence may differ by one or more nucleotides
  ATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTG
  GGCAGCGTCGGGGATGTCCCCTTCACGGCATATGGATCAGGCTGTGATATTGTTATTTTG
  GCAAATGACTTTGAATGTGTACAGATCATTCCTGGTGCTAAGCATGGAAACATCCAAGTC
  AGCTGTGTGGAGTGTTCTAACCAACAAGGAAGAATTGCAGCTTCATATGGTAATGCTGTT
  TGTATATTTGAGCCCTTGGGCATAAATTCTCATAAAAGAAATTGTCAACTCAAGTGCCAG
  TGGCTTAAAACTGGGCAGTTTTTTTTGAGTTCTGTGACATACAACTTAGCATGGGATCCT
  CAAGATAATAGATTGTTGACAGCAACTGATTCTATTCAGTTGTGGGCTCCTCCAGGAGAT
  GATATTCTGGAAGAGGAGGAAGAAATTGATAATACAGTTCCTCCTGTTTTAAATGATTGG
  AAGTGTGTCTGGCAGTGCAAAACCTCAGTATCTGTACATTTGATGGAATGGTCTCCTGAT
  GGTGAATATTTTGCTACTGCTGGAAAGGATGATTGTCTTTTGAAAGTGTGGTATCCTATG
  ACTGGTTGGAAGTCTTCAATTATACCTCAGGATCATCATGAAGTAAAAAGGAGACAGTCC
  TCTACTCAATTTTCTTTTGTTTACTTGGCACATCCCCGAGCTGTGACAGGTTTTTCGTGG
  CGCAAAACTAGCAAGTATATGCCCAGGGGTTCTGTCTGTAATGTGTTGTTAACTTCATGT
  CATGATGGTGTGTGCCGGCTCTGGGCAGAAACTTTATTACCAGAAGACTGTCTTTTGGGT
  GAGCAGATTTGTGAGACTACCACTTCCAGCATTGCCAGCAGCCTTTCTCATGCTGGAAGA
  CACAAAGACAGAATACAGCATGCTCTTGAGACAATACACCATTTGAAAAATTTAAGGAAA
  GGACAGAGGAGGTCATCTGTTCTTGTAACTCATGCTGAATTAATGCCCGACCAGACAGCA
  ATGCATGAAGTTCAAAGACACATTTCCCACCATGCAAATGCACTCTGTCATTTTCATATT
  GCAGCAAGCATCAACCCTGCCACAGATATTCCAAATGTCTTGGTTGGCACTGCATTTAAT
  GTTGATGATGGAAATGGGGGCTTTGTAGTTCATTGGTTAAACAACAAGGAATTTCATTTT
  ACATCATCTACAGAAGTATTTATGCATCAATTACGAAAACTTTCTGATAAGCAGGTAGAT
  CATGAAAATGATGATGCAGATAGAGAAGATGAGGAACATTCACAGGAGGATAGAGAACGG
  GGTTTACATATGAAATTAGACCATGATTTATCCCTGGATAGAGAATCTGAGGCAGGTACA
  GGATCATCAGAACATGAAGATGGAGAAAGAGAAGGAAGTCCTAGAACTTACTCACGACTT
  AGTGTACCAATGCCACTGCCTACGGTTCTGCTTGATCGGAAGATTGAAACGCTGCTAACT
  GAATGGAATAAGAATCCTGATATGCTTTTTACAATACACCCTGTAGATGGTACCTTTCTA
  GTGTGGCATGTGAAGTATTTGGATGAATATAATCCTGGAATATTTAGACAAGTTCAGGTT
  TCTTTTTCTTCTCGGATTCCTGTTGCATTTCCCTCTGGTGATGCAAGCTCTCTTAGTAAA
  AATATCATGATGTATGCCTGTATAAATGCGACAAAAGATTCTCACCACACGCTGTTACAC
  CAGGAGGGGATGTCTGTAGGCAGTCCTCACGGATCACAGCCACACTCTAGATCCCACAGT
  ACACATATGAACATCTTAGCTCCCACAGTAATGATGATCTCTAAACACATAGATGGTTCT
  TTAAATCAGTGGGCAGTCACTTTTGCTGATAAGTCTGCCTTTACCACTGTTCTAACTGTA
  TCTCACAAATTTAGATATTGCGGTCATCGATTTCACCTCAATGACCTGGCATGTCATTCA
  GTTTTACCACTGTTATTGACATCCTCTCATCATAATGCTCTATTGACTCCTGAATTAGAT
  TGTCAGTGGGACTCAGACAATAAATTAAGTAGATTAATGGACCCTGTAAAACATATAAAA
  GGTTCCTCGAAACAACCTCTTAGAAATGCAGCAACTCGTACATTTCATGACCCAAATGCA
  ATCTACAGTGAACTTATTCTGTGGCGTGTAGACCCAATAGGACCTTTGTCATACACTGGA
  GGAGTATCAGAATTGGCTCGAATTAACTCTTTACATACCTCAGCGTTCTCTAATGTGGCT
  TGGCTTCCAACTCTCATTCCCAGTTACTGTCTAGGCACATACTGCAATTCTGCAAGTGCT
  TGCTTTGTTGCTTCTGATGGCAAAAATCTGAGACTCTATCAAGCTGTAGTGGATGCAAGG
  AAATTATTAGATGAATTGTCAGACCCAGAATCTTCAAAACTTATTGGAGAAGTGTTTAAT
  ATTGTGAGCCAACAGTCTACTGCTCGACCTGGCTGCATTATTGAACTCGACGCAATAACC
  AACCAATGTGGCTCAAATACACAGTTGCTTCATGTGTTTCAAGAAGACTTCATTATAGGA
  TATAAACCACATAAGGAAGATATGGAGAAAAAGGAAACAGAAATATTTTTTCAGCCATCA
  CAAGGATACCGCCCACCACCATTTTCAGAAAAGTTCTTTCTAGTAGTAATTGAGAAGGAC
  AGCAATAATAACTCTATTCTGCATATGTGGCACCTTCATCTTAAATCTGTACAAGCATGT
  TTAGGAAGAGATACATTAGATGAGTGTGGTTTGAGATACTTGTTAGCTATGCGCCTACAC
  ACATGCCTTTTGACATCGCTGCCTCCTTTATACCGAGTGCAGCTACTTCATCAAGGTGTC
  TCTACATGCCATTTTGCCTGGGCTTTTCATTCTGAGGCTGAAGAAGAACTGATTAATATG
  ATTCCAGCAATTCAGAGAGGGGACCCCCAGTGGTCTGAATTAAGAGCTATGGGCATAGGA
  TGGTGGGTGAGGAACATTAACACGCTTCGAAGATGCATTGAAAAGGTTGCCAAAGCTTCT
  TTTCAAAGGAACAATGATGCCTTAGATGCTGCACTATTCTACCTTTCAATGAAGAAGAAA
  GCAGTAGTGTGGGGTCTGTTTAGGTCACAGCATGATGAAAAAATGACAACATTTTTCAGC
  CACAACTTTAATGAAGATAGATGGCGAAAAGCTGCTTTGAAAAATGCTTTTTCCTTACTT
  GGAAAACAACGCTTTGAACAATCGGCTGCTTTTTTCTTGCTAGCTGGTTCATTGAAAGAT
  GCCATAGAGGTATGTCTTGAAAAAATGGAAGATATTCAGCTAGCCATGGTTATTGCCCGT
  TTATATGAATCTGAATTTGAGACTTCATCCACTTATATATCCATCCTAAATCAGAAGATT
  TTGGGTTGCCAAAAGGATGGCTCAGGATTCAGTTGCAAAAGATTACATCCTGATCCTTTC
  CTGCGTAGTCTTGCCTATTGGGTAATGAAAGATTACACCCGAGCCTTGGACACATTACTG
  GAACAAACACCAAAGGAGGATGATGAACATCAAGTTATCATCAAGTCTTGTAACCCGGTG
  GCATTTAGTTTTTATAACTACCTTCGAACTCATCCTTTGCTCATTCGAAGAAATCTTGCC
  TCCCCTGAAGGAACTTTGGCAACCTTAGGTCTCAAAACTGAGAAGAACTTTGTTGATAAA
  ATTAACCTCATAGAAAGAAAATTATTCTTTACCACTGCAAATGCTCATTTTAAAGTTGGA
  TGCCCTGTTTTAGCCTTGGAGGTACTCTCCAAAATTCCAAAAGTAACCAAAACATCTGCC
  TTATCTGCAAAAAAAGATCAGCCTGACTTCATTTCTCACAGGATGGATGATGTACCTTCA
  CATTCAAAAGCTCTGAGTGATGGCAATGGAAGTTCTGGCATTGAATGGTCAAATGTAACT
  TCATCACAGTATGACTGGAGTCAGCCAATAGTAAAAGTTGATGAGGAACCTCTTAATCTT
  GATTGGGGTGAAGATCACGACAGTGCCTTAGATGAAGAGGAAGACGATGCTGTTGGTTTA
  GTGATGAAAAGTACAGATGCCAGGGAAAAAGATAAACAATCAGATCAGAAGGCCTCAGAC
  CCTAACATGTTATTAACACCTCAGGAAGAGGATGATCCTGAAGGTGATACTGAAGTTGAT
  GTGATTGCTGAACAACTAAAATTCAGAGCTTGTTTAAAGATCCTTATGACTGAATTAAGA
  ACATTGGCTACAGGTTATGAAGTAGATGGAGGAAAACTCAGATTTCAACTCTATAACTGG
  CTTGAAAAGGAAATTGCTGCCTTGCATGAGATATGTAATCATGAATCAGTTATTAAAGAG
  TATTCCAGTAAGACATATTCCAAAGTAGAGAGTGATCTGCTGGATCAGGAAGAAATGGTA
  GACAAACCAGATATTGGTTCCTATGAGCGCCATCAAATAGAAAGAAGAAGATTGCAGGCC
  AAACGAGAGCATGCAGAAAGACGAAAGTCGTGGTTGCAGAAAAACCAAGATCTCCTGAGA
  GTATTTCTCAGCTACTGTAGCCTTCATGGGGCCCAAGGTGGTGGTTTGGCTTCAGTAAGG
  ATGGAACTCAAATTTTTGCTACAAGAATCACAACAGGAAACTACAGTAAAGCAGCTCCAG
  TCTCCACTACCACTGCCTACCACCCTACCTCTGCTTTCAGCAAGTATTGCGTCAACAAAA
  ACAGTCATAGCTAATCCTGTATTGTACTTAAATAATCACATCCATGATATACTTTATACT
  ATTGTTCAGATGAAAACACCACCTCATCCCAGTATTGAAGATGTGAAGGTGCACACACTT
  CATTCACTAGCAGCATCACTTTCTGCATCAATTTACCAAGCATTATGTGACAGTCATAGC
  TACAGTCAAACAGAAGGAAATCAGTTTACAGGAATGGCTTATCAAGGACTTCTTTTAAGT
  GATCGTAGAAGACTAAGGACAGAAAGCATTGAAGAACACGCAACACCAAATTCATCTCCT
  GCTCAATGGCCTGGTGTGAGCTCACTTATTAATCTTTTGAGTTCAGCCCAAGATGAAGAC
  CAGCCAAAACTGAACATTTTGCTATGTGAAGCTGTTGTTGCTGTTTACTTAAGTTTATTG
  ATACATGCTCTTGCCACAAATTCCTCCAGTGAATTATTTCGGCTTGCAGCCCACCCATTA
  AATAATCGAATGTGGGCTGCTGTTTTTGGAGGCGGTGTAAAACTTGTTGTGAAACCTCGA
  AGACAATCAGAAAATATTTCAGCACCTCCTGTCCTTTCTGAAGACATAGATAAACACCGT
  AGGAGATTTAACATGAGAATGCTCGTCCCTGGAAGGCCTGTAAAAGATGCTACCCCACCA
  CCGGTGCCTGCAGAAAGACCATCTTACAAAGAAAAATTTATTCCTCCCGAACTTAGTATG
  TGGGATTATTTTGTTGCAAAGCCATTTCTTCCTTTGTCTGATAGTGGTGTTATATATGAT
  TCTGATGAAAGCATTCATAGTGATGAAGAAGATGATGCCTTTTTTTCAGATACACAAATA
  CAGGAGCACCAAGATCCAAATTCCTATAGCTGGGCTCTTCTACATTTGACAATGGTTAAA
  CTAGCACTTCACAATGTCAAGAATTTCTTTCCTATTGCTGGACTGGAATTCTCTGAGCTG
  CCTGTAACATCACCATTAGGTATTGCTGTGATTAAAAACTTGGAGAACTGGGAACAGATC
  TTGCAAGAGAAAATGGATCAGTTTGAAGGTCCACCCCCTAACTATATCAACACATATCCA
  ACTGACCTTTCAGTGGGAGCTGGACCAGCTATTCTTCGAAATAAAGCAATGCTAGAACCT
  GAAAATACCCCATTCAAGTCCCGGGATTCTTCTGCATTTCCAGTCAAACGACTTTGGCAT
  TTCCTTGTTAAACAAGAGGTCCTTCAAGAGACATTTATTAGATATATTTTCACTAAGAAA
  AGAAAGCAGAGTGAGGTTGAAGCTGATCTGGGCTATCCAGGTGGAAAGGCGAAAGTCATC
  CATAAGGAATCTGATATGATCATGGCATTTTCTGTTAATAAGGCAAATTGTAATGAAATT
  GTTTTGGCTTCAACACATGATGTTCAAGAACTTGATGTTACTTCTCTACTGGCCTGTCAG
  TCATACATATGGATCGGAGAAGAATATGACAGAGAATCCAAAAGTTCAGATGATGTTGAT
  TATCGTGGTTCCACTACAACTCTTTATCAACCCAGTGCAACATCCTATTCAGCAAGTCAG
  GTGCATCCACCTTCATCTCTGCCATGGCTGGGCACTGGACAGACTAGCACTGGAGCTAGT
  GTGCTTATGAAAAGGAATCTACATAATGTTAAGAGAATGACTTCACACCCAGTCCATCAA
  TACTATCTTACAGGTGCTCAGGACGGCAGTGTACGAATGTTTGAATGGACGCGGCCTCAG
  CAACTTGTCTGCTTTCGTCAAGCTGGCAATGCAAGAGTTACTAGATTATATTTTAATTCA
  CAAGGCAACAAGTGTGGTGTTGCGGATGGAGAGGGTTTTCTGAGTATCTGGCAAGTTAAC
  CAAACTGCATCAAATCCTAAACCTTATATGAGTTGGCAGTGCCACAGTAAAGCCACAAGT
  GACTTTGCATTTATTACCTCTTCAAGTCTAGTTGCCACATCTGGACACTCCAATGACAAT
  AGAAATGTTTGCCTCTGGGACACATTAATATCACCCGGAAACAGCCTCATTCATGGTTTC
  ACGTGCCACGATCATGGTGCCACGGTACTGCAGTATGCACCCAAACAGCAACTCCTAATC
  TCGGGGGGTAGGAAAGGACACGTCTGCATTTTTGACATCAGGCAAAGGCAGCTCATTCAC
  ACGTTCCAGGCCCATGACTCAGCTATTAAGGCTCTGGCCTTGGATCCCTATGAGGAATAT
  TTTACCACAGGTTCAGCAGAAGGTAACATAAAGGTTTGGAGATTGACAGGCCATGGCCTA
  ATTCATTCATTTAAAAGTGAACATGCTAAGCAGTCCATATTTCGAAACATTGGGGCTGGA
  GTCATGCAGATTGACATCATCCAGGGCAATCGGCTCTTCTCCTGTGGTGCAGATGGCACG
  CTGAAAACCAGGGTTTTGCCCAATGCTTTTAACATCCCTAACAGAATTCTTGACATTCTA
  TAA
  
• Restriction Sites: Please inquire
• ACCN: NM_001174117
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001174117.1, NP_001167588.1
• RefSeq Size: 8688 bp
• RefSeq ORF: 7203 bp
• Locus ID: 23312
• UniProt ID: Q8TDJ6
• Cytogenetics: 15q21.2
• Gene Summary: This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (3) lacks two coding exons compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C- termini compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.