TIP30 (HTATIP2) (NM_006410) Human Untagged Clone

CAT#: SC320649

HTATIP2 (untagged)-Human HIV-1 Tat interactive protein 2, 30kDa (HTATIP2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TIP30
• Synonyms: CC3; SDR44U1; TIP30
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006410.3 GGATGCTCTGATGGCCGGGCCTGCGGCGCTGAGCGCGGCGGCGGCGGCTGCTCTGGCGGC
  CGCCCTGCTCCTGCTGCGTCGTGAGGACCCGGGGCCGGGGGCTGGCCCCAGCATGGCCGA
  AACAGAAGCCCTGTCGAAGCTTCGGGAAGACTTCAGGATGCAGAATAAATCCGTCTTTAT
  TTTGGGCGCCAGCGGAGAAACCGGCAGAGTGCTCTTAAAGGAAATCCTGGAGCAGGGCCT
  GTTTTCCAAAGTCACGCTCATTGGCCGGAGGAAGCTCACCTTCGACGAGGAAGCTTATAA
  AAATGTGAATCAAGAAGTGGTGGACTTTGAAAAGTTGGATGACTACGCCTCTGCCTTTCA
  AGGTCATGATGTTGGATTCTGTTGCCTGGGTACCACCAGAGGGAAAGCTGGGGCGGAGGG
  ATTTGTTCGTGTTGACCGAGATTATGTGCTGAAGTCTGCAGAGCTGGCAAAAGCTGGAGG
  GTGCAAACATTTCAACTTGCTATCCTCTAAAGGAGCTGATAAATCAAGCAATTTTTTATA
  TCTACAAGTTAAGGGAGAAGTAGAAGCCAAGGTTGAAGAATTAAAATTTGATCGTTACTC
  TGTATTTAGGCCTGGAGTTCTGTTATGTGATAGGCAAGAATCTCGCCCAGGTGAATGGCT
  GGTTAGAAAGTTCTTTGGCTCCTTACCAGACTCTTGGGCCAGGGGGCATTCTGTGCCTGT
  GGTGACCGTGGTTAGAGCAATGCTGAACAATGTGGTGAGACCAAGAGACAAGCAGATGGA
  ACTGCTGGAGAACAAGGCCATCCATGACCTGGGGAAAGCGCATGGCTCTCTCAAGCCATG
  ACCACACTGGAGAAATGGTTTTTATTGTCAACCTTAACACCCATCACCAAATCGGTAATT
  TCAGGGTCTAAAAAAAGTCAGCATGTTTTAACTTTGTTGTTTTACTATCCTCAGGCATCC
  ATTCCAATCAAGAAATGATGGTGCTCTGCATCAGTGGTTCAGAGCCTGGTTATACATATA
  GATCACTCAGGGAGCTTTGGAAAAATAAAGATTTGTCAGCCCTATCTCAAACTTGAATCA
  AAATTTCTGGGGTGTGGGCACAATAATCTGTAATTTTCTTTGTTTATACTTCCCCTGATG
  CCACTGGTTCCGATGCCACTGGCTGGGGGGCCTGCTTTGAAATGCTTGTCTGCAGAGTCA
  CAGCAGCCATGAAAACCTTATGACCGTGCAAATGAGCTCTGCTCTAAAATTGTTGACATT
  CATGTCTCTGAGTTACAAAAGTGCTAATTCACTACATGTAATTGTGTAAGTAAACATTGT
  GCCTTTACTACTTCTTTATGTAATAGAAGTTATATACCTAAGCTTATATAATACATGGGG
  AGGATTAAATAAAGGAATAAAGATGAATGGACAACTCCAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_006410
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_006410.3, NP_006401.2
• RefSeq Size: 1438 bp
• RefSeq ORF: 729 bp
• Locus ID: 10553
• UniProt ID: Q9BUP3
• Cytogenetics: 11p15.1
• Protein Families: Druggable Genome
• Gene Summary: Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) uses an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.