USP51 (NM_201286) Human Untagged Clone

CAT#: SC314496

USP51 (untagged)-Human ubiquitin specific peptidase 51 (USP51)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: USP51
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_201286, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCCAGGTTCGAGAAACTTCTTTGCCCTCCGGCTCTGGGGTCCGCTGGATCTCCGGAGGTGGGGGAG
  GAGCCTCTCCTGAGGAGGCGGTTGAGAAGGCGGGGAAAATGGAGGAGGCGGCGGCGGGGGCTACGAAGGC
  GTCTTCGAGACGTGAAGCCGAGGAGATGAAGCTGGAGCCATTACAAGAGCGTGAGCCCGCGCCGGAGGAG
  AACTTGACGTGGAGCAGCAGCGGCGGCGACGAGAAGGTGCTCCCTTCAATCCCCCTTCGCTGTCACAGCA
  GCTCCTCGCCCGTTTGCCCGCGCCGCAAGCCCCGCCCTCGGCCCCAGCCCCGGGCCCGCTCCCGCAGCCA
  GCCTGGGCTCTCGGCCCCACCCCCGCCTCCAGCCCGGCCCCCGCCCCCGCCGCCACCCCCGCCCCCACCC
  GCACCGCGGCCCAGGGCCTGGCGTGGATCCCGGCGCAGATCCCGGCCTGGGTCCAGGCCTCAGACACGGA
  GAAGCTGCTCTGGTGACCTAGACGGGTCGGGGGATCCTGGCGGCTTAGGGGACTGGTTGCTGGAGGTCGA
  GTTTGGTCAGGGTCCCACAGGCTGCTCTCATGTGGAGAGCTTTAAAGTAGGTAAGAACTGGCAGAAGAAC
  CTGAGGTTGATCTACCAGCGTTTCGTTTGGAGTGGGACCCCAGAGACTAGGAAACGTAAAGCAAAGTCAT
  GCATCTGTCACGTATGTAGTACCCATATGAACAGACTCCACTCTTGTCTCTCCTGTGTCTTTTTTGGCTG
  CTTCACTGAGAAACATATTCACAAACATGCAGAAACAAAGCAGCACCATTTAGCTGTAGACCTTTATCAT
  GGGGTCATATATTGCTTCATGTGTAAGGATTATGTATATGACAAAGACATAGAACAGATTGCCAAAGAAA
  CAAAAGAAAAAATTTTGAGATTATTAACTTCCACCTCAACAGATGTTTCTCATCAACAGTTTATGACATC
  AGGGTTTGAAGACAAGCAATCAACCTGTGAGACAAAGGAACAGGAGCCAAAATTGGTGAAACCCAAGAAA
  AAGAGAAGAAAAAAGTCAGTCTATACTGTAGGCCTGAGAGGGCTAATCAATCTTGGGAACACTTGTTTTA
  TGAATTGTATTGTCCAGGCACTTACCCATATTCCTCTACTGAAAGATTTCTTCCTCTCTGACAAGCACAA
  ATGTATAATGACAAGCCCCAGCTTGTGTCTGGTCTGTGAAATGTCTTCGCTTTTTCATGCTATGTACTCT
  GGGAGCCGAACTCCTCACATTCCCTATAAGTTACTGCATCTGATATGGATCCATGCAGAACATTTAGCAG
  GGTACAGGCAGCAGGATGCCCATGAGTTCCTTATTGCAATATTAGACGTGCTACATAGACACAGCAAAGA
  TGATAGTGGTGGGCAGGAGGCCAATAACCCCAACTGCTGTAACTGCATCATAGACCAAATCTTTACAGGT
  GGCCTGCAATCAGATGTCACATGTCAAGCCTGCCATAGTGTTTCTACCACCATAGACCCATGCTGGGACA
  TCAGTTTGGACTTGCCTGGCTCTTGTGCCACATTCGATTCCCAGAACCCAGAGAGGGCTGACAGCACAGT
  GAGCAGGGATGACCACATACCAGGAATCCCCTCACTTACAGACTGTCTACAGTGGTTTACAAGGCCAGAG
  CACCTAGGAAGCAGTGCCAAAATCAAATGCAATAGTTGCCAAAGCTACCAGGAGTCTACTAAACAGCTCA
  CAATGAAAAAATTACCCATTGTGGCTTGTTTTCATCTCAAGCGGTTTGAGCATGTAGGCAAACAGAGGCG
  AAAGATTAATACCTTTATCTCCTTTCCCTTGGAGCTGGACATGACTCCGTTTTTGGCCTCTACTAAAGAG
  AGCAGAATGAAAGAAGGCCAGCCACCAACAGATTGTGTGCCCAATGAGAATAAGTATTCCTTGTTTGCAG
  TGATTAATCACCATGGAACTTTGGAAAGTGGCCACTATACCAGCTTCATCCGGCAACAAAAGGACCAGTG
  GTTCAGCTGTGATGATGCCATCATCACCAAGGCTACCATTGAGGACTTACTCTACAGTGAAGGGTATTTA
  CTGTTCTATCACAAACAGGGTCTAGAGAAAGACTAG
  
  
• Restriction Sites: Please inquire
• ACCN: NM_201286
• Insert Size: 3200 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of clone has been fully sequenced and found to be a perfect match to NM_201286.2.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_201286.2, NP_958443.1
• RefSeq Size: 2490 bp
• RefSeq ORF: 2136 bp
• Locus ID: 158880
• UniProt ID: Q70EK9
• Cytogenetics: Xp11.21
• Protein Families: Druggable Genome, Protease
• Gene Summary: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).[UniProtKB/Swiss-Prot Function]