TEA domain family member 2 (TEAD2) (AK093236) Human Untagged Clone

CAT#: SC313529

(untagged)-Human cDNA FLJ35917 fis, clone TESTI2010409, highly similar to TRANSCRIPTIONAL ENHANCER FACTOR TEF-4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TEAD2
• Synonyms: ETF; TEAD-2; TEF-4; TEF4
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for AK093236, the custom clone sequence may differ by one or more nucleotides
  ATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAG
  GAAGGCAGTGAGGAGGGTACCGGCGGCAGTGAGGGGGCTGGGGGTGACGGGGGCCCGGAT
  GCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTAT
  CCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAAT
  GAACTGATCGCCCGCTACATCAAGCTGAGAACGGGGAAGACCCGAACTCGAAAACAGGTT
  TCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAAG
  GACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTC
  ATCTCCGCGCCTTCTCTGCAGGCCAAACTGGGTCCCACTGGTCCTCAGGTGGTCCAGGCC
  TCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGATGTG
  AAGCCATTCTCACAGACACCGTTCACCTTGTCACTGACTCCCCCATCTACTGACCTCCCA
  GGGTACGAGCCCCCCCAAGCCCTCTCACCCCTGCCCCCACCTACCCCATCGCCCCCAGCC
  TGGCAGGCTCGGGGCCTGGGCACCGCCCGGTTGCAGCTGGTAGAGTTCTCAGCCTTCGTG
  GAACCGCCAGATGCAGTTGATTCTTACCAGAGGCACCTGTTCGTGCACATCAGCCAGCAC
  TGCCCCAGCCCCGGAGCGCCGCCGCTCGAGAGTGTGGACGTCCGGCAGATCTACGACAAA
  TTCCCTGAGAAAAAGGGCGGCCTCCGAGAGCTATATGATCGTGGCCCCCCCCATGCCTTC
  TTCCTGGTCAAGTTCTGGGCGGACCTGAACTGGGGCCCAAGTGGTGAGGAGGCAGGGGCC
  GGTGGCAGCATCAGCAGTGGTGGCTTCTACGGAGTGAGCAGCCAGTATGAGAGCCTGGAA
  CACATGACCCTCACCTGTTCCTCCAAGGTCTGCTCTTTTGGCAAGCAGGTGGTGGAGAAG
  GTGGAGACGGAACGGGCCCAGCTGGAGGACGGCAGATTTGTGTACCGCCTGCTGCGCTCG
  CCCATGTGCGAGTACCTGGTGAATTTCTTGCACAAGTTGCGGCAGCTGCCTGAGCGATAC
  ATGATGAACAGCGTCCTGGAAAACTTCACCATCCTCCAGGTGGTGACAAACAGAGACACC
  CAGGAACTGCTGCTCTGCACCGCCTATGTCTTCGAGGTCTCCACCAGCGAGCGTGGGGCC
  CAGCATCACATTTACCGCCTGGTCAGGGAC
  
• Restriction Sites: Please inquire
• ACCN: AK093236
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: AK093236.1, BAC04104.1
• RefSeq Size: 2442 bp
• RefSeq ORF: 2442 bp
• Locus ID: 8463
• Cytogenetics: 19q13.33
• Domains: TEA
• Protein Families: Transcription Factors
• Gene Summary: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.[UniProtKB/Swiss-Prot Function]