WWOX (NM_130790) Human Untagged Clone
CAT#: SC309099
WWOX (untagged)-Human WW domain containing oxidoreductase (WWOX), transcript variant 3
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Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | WWOX |
Synonyms | FOR, WOX1, FRA16D, HHCMA56, PRO0128, WWOX v8, D16S432E |
Vector | pCMV6-XL5 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene sequence for NM_130790 edited
GAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCAC AGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGC TGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACA CCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAG ATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACC ATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATC CGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCC AGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGCAA CAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGG ATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACG GCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCC GGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACG CAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAG GAAATAAGAGCATTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATT CCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGG TGGTGGCCTGTTTGAAAGTAAAAACCTGGTTGGCGTGTAGGTTCCGTATCTCCCTGGAAA AGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTC >OriGene 5' read for NM_130790 unedited
GTCAAAATTTGTATACGACTCATATAGGCGGCCGCGNAATCAAATCTGGTACCGAGCTCG GATCCACTAGTAACGGCCGCCAGTGTGCTGGAATTCGCCCTTGAGTGAGTTCCTGAGCGA GTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGC TGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGG AGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGT GGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGG AACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCA CCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCC GGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTG GCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGCAACAGGGAGCTGCCACCACC GTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGC TGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCG CTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGA GCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCN >OriGene 3' read for NM_130790 unedited
CCATGGNGATGGCACTTCCAGGNCCAGGNANAGCACTGGGGNAGGGTCACAGGGATGCCA CCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGATGCATGCTCGAGC GGCCGCCAGTGTGATGGATATCTGCAGAATTCGCCCTTCGAGGGGACCTCAGGCTATTCT ATAACAGTAAAAGAAAGAGAATTGCTGGTGCTTTTCCAGGGAGATACGGAACCTACACGC CAACCAGGTTTTTACTTTCAAACAGGCCACCACCAGAAAGCAAAGAGACCTATGCCTAGC CCAGCCCCAGAAAAGTGATACTTTACCCCAGGAATTCCCTGCTTCCCATTGGTACTTAAG ATTTTTCACTCTGTTGTGAATGCTCTTATTTCCTTTACTCTTGCGGATCTGTGTTGGAGG GACATTTGGAAGGGGCCCAGCCCTGGCACTTGCGTGAGGGGACACACACAGGGCGGGTGT GTGTGCCCATCCGCTCTGAGCTCCACTTAGCCGGACTGGCTGCCAAGCCGTTCTTGGATC AGCCTCTCGCTGAGCGCCCACAGGGTCCGGGCCGTCTCTTCGCTCTGAGCTTCTGGTGAG GGCATGCAGCGGCAGCAGTTGTTGAAGTACATCCCTCCCAGACCCTCCAGTTCTGGGACA GCAGCACAGTACACGGTGGTGGCAGCTCCCTGTTGCTATTCCTGAATTAGCTCCAGTGAC CACAACCACTTTGCCAGTGAAATCCCGGCCCTGGANAAATTCCATGGCAGTGGTGCTGCC GTCGTATCTTTGCCCGGTGGTTGGGCTTGGTCGGATTATCATCCACCAGTAACGCCCAGT CTTGGGTCCCAAGTAGTGGGTTCTTTTATTTATATGGGTCAC |
Restriction Sites | Please inquire |
ACCN | NM_130790 |
Insert Size | 1000 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_130790.1, NP_570606.1 |
RefSeq Size | 1617 bp |
RefSeq ORF | 1617 bp |
Locus ID | 51741 |
Cytogenetics | 16q23.1-q23.2 |
Protein Families | Druggable Genome |
Gene Summary | This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Transcript Variant: This variant (3) lacks a 647 nt fragment in the middle part of the coding region, as compared to variant 1. The absence of the internal fragment shifts the reading frame and results in a smaller isoform (3) which lacks the SRD region and has a different C-terminus from that of isoform 1. |
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