LZTS2 (NM_032429) Human Untagged Clone

CAT#: SC305446

LZTS2 (untagged)-Human leucine zipper, putative tumor suppressor 2 (LZTS2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LZTS2
• Synonyms: LAPSER1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_032429 edited
  CTGGAGCCGAGGCGCAGGTGGCGCTGGGTTGCCTGCGAGGCCGCTGGCCAGGCCTGAGCC
  TCTGCCACCATGGCCATTGTGCAGACTCTGCCAGTGCCACTGGAGCCTGCTCCTGAAGCT
  GCCACTGCCCCACAAGCTCCAGTCATGGGTAGTGTGAGCAGCCTTATCTCAGGCCGGCCC
  TGTCCCGGGGGGCCAGCTCCTCCCCGCCACCACGGCCCTCCTGGGCCCACCTTCTTCCGC
  CAGCAGGATGGCCTGCTACGGGGTGGCTATGAGGCACAGGAGCCGCTGTGCCCAGCTGTG
  CCCCCTAGGAAGGCTGTCCCTGTCACCAGCTTCACCTACATCAATGAGGACTTCCGGACA
  GAGTCACCCCCCAGCCCAAGCAGTGATGTTGAGGATGCCCGAGAGCAGCGGGCACACAAT
  GCCCACCTCCGCGGCCCACCACCAAAGCTCATCCCTGTCTCTGGAAAGCTGGAGAAGAAC
  ATGGAGAAGATCCTGATCCGCCCAACAGCCTTCAAGCCAGTGCTGCCCAAACCTCGAGGG
  GCTCCGTCCCTGCCTAGCTTCATGGGTCCTCGGGCCACCGGGCTGTCTGGGAGCCAGGGC
  AGCCTGACGCAGCTGTTTGGGGGCCCTGCCTCCTCCTCCTCCTCTTCCTCCTCCTCTTCA
  GCTGCTGACAAACCCCTGGCATTTAGTGGCTGGGCCAGTGGCTGCCCATCAGGGACGCTA
  TCCGACTCTGGCCGAAACTCACTGTCCAGCCTGCCCACCTACAGCACCGGAGGTGCCGAG
  CCAACCACCAGCTCCCCAGGCGGGCACCTGCCTTCCCATGGCTCTGGGCGAGGGGCACTG
  CCTGGGCCAGCCCGAGGGGTCCCTACTGGGCCCTCCCACTCAGACAGTGGCCGGTCCTCC
  TCCAGCAAGAGCACAGGCTCCCTAGGGGGCCGTGTGGCTGGGGGGCTTTTGGGCAGTGGT
  ACTCGGGCCTCCCCTGACAGCAGCTCCTGTGGGGAGCGCTCACCACCACCCCCGCCTCCA
  CCTCCTTCGGATGAGGCCCTGCTGCACTGTGTCCTGGAAGGAAAGCTCCGAGACCGGGAG
  GCAGAGCTTCAGCAGCTGCGGGACAGTCTGGACGAGAATGAGGCTACCATGTGCCAGGCA
  TACGAGGAGCGGCAGCGGCACTGGCAGCGAGAGCGTGAGGCCCTGCGAGAGGACTGTGCG
  GCCCAGGCACAGCGGGCACAGCGGGCCCAACAGCTGCTGCAGCTGCAGGTGTTCCAGCTG
  CAGCAGGAGAAGCGGCAATTGCAGGACGACTTCGCACAGCTGCTGCAGGAGCGCGAACAG
  CTGGAGCGGCGCTGCGCCACCTTGGAGCGGGAGCAGCGGGAGCTCGGGCCGAGGCTTGAG
  GAGACCAAGTGGGAGGTGTGCCAGAAATCAGGCGAGATCTCCCTGCTGAAGCAGCAGCTG
  AAAGAGTCTCAGGCAGAGCTGGTGCAGAAGGGCAGCGAGCTGGTGGCTCTGCGGGTGGCG
  CTGCGGGAGGCCCGTGCTACGCTGCGGGTCAGTGAGGGCCGTGCGCGGGGTCTACAGGAG
  GCCGCCCGAGCTCGGGAGCTGGAGCTGGAAGCCTGTTCCCAGGAGCTGCAGCGACACCGC
  CAGGAAGCTGAGCAGCTGCGGGAGAAAGCTGGGCAGTTGGATGCTGAGGCGGCCGGACTC
  CGGGAGCCCCCTGTGCCACCTGCCACCGCTGACCCATTCCTCCTGGCAGAGAGTGATGAG
  GCCAAAGTGCAGCGGGCAGCAGCCGGGGTTGGGGGCAGCTTGCGGGCCCAGGTGGAGCGA
  TTGCGGGTGGAGCTGCAGCGGGAGCGGCGGCGGGGTGAGGAGCAGCGGGACAGCTTTGAG
  GGGGAGCGGCTGGCCTGGCAGGCAGAGAAGGAGCAGGTGATCCGCTACCAGAAGCAGCTG
  CAGCACAACTACATCCAGATGTACCGGCGCAACCGGCAGCTAGAGCAGGAGCTGCAGCAG
  CTCAGCCTGGAGCTGGAGGCCCGGGAGCTCGCTGACCTGGGCCTGGCCGAGCAGGCCCCC
  TGCATCTGCCTGGAGGAGATCACTGCTACTGAGATCTAGGGCCCTCAGCAACCAGCTCTG
  TAGGGAGCTCTGCCAGAGGGGCAGCAGCTGCAGATCCACTTAGGCCCCAGGGTCCACGGA
  TGGCCCCAAAGGCTGAGGGCCCCAAAGCCACTTGTCTCCTAGGATCCAGGCCTCTGGGCT
  TCTGCCAAGAACTCAGGGTGGCCCTATGACTTGGAGGAGCAAGATCAGACCGCTCAAAGG
  TCCCCGTGTTCACTGTTACCCAGAGGCTCTTGTTACTACCCACTTCATTCCCCACCGCTG
  CCAGTGCCACTGCCAACCCTGTTCACAGGCGCTTCCAGCCCACTCCAGCCAGGGGAGCAG
  GGAAGAAGAAGGGGCTCCCTCCTCTTCACATTCCCCCCGACCCCAAAGCCAGAGAAAGCC
  AGATGGCACCAGCTGCTCCGGATGTGCCTGCCCACATTGGGGGACAGGGCCGGGCCTGGG
  CTCGGTTCCCAGGTTTGAGCTCTGCAGCCTCTCTCCTGGAGTGAGGGGGCTGAAGTCAGA
  CCAAAGGAAGAACTCAGAAATGTCTTGTTTATTTGTGTTTGTGACCAAGCAGCCTCTCCC
  TTCACCCAGGTTTATGGCCTCGTTTTCACTTGTATATTTTTCACACTGTAAATTTCTTGT
  ACAAACCCAAAGAAAAAATTAAAAAAAATTTTTTTGTTTAAAAAAAAAAAAAAAAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_032429
• Insert Size: 2700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_032429.1.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_032429.1, NP_115805.1
• RefSeq Size: 2757 bp
• RefSeq ORF: 2010 bp
• Locus ID: 84445
• UniProt ID: Q9BRK4
• Cytogenetics: 10q24.31
• Protein Families: Druggable Genome
• Gene Summary: The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 all encode isoform a.