Antizyme inhibitor 1 (AZIN1) (NM_015878) Human Untagged Clone
CAT#: SC125518
AZIN1 (untagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 1
"NM_015878" in other vectors (7)
Product Images
![](https://cdn.origene.com/img/defaults-img-expression-plasmids.jpg)
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | Antizyme inhibitor 1 |
Synonyms | AZI; AZI1; AZIA1; OAZI; OAZIN; ODC1L |
Vector | pCMV6-XL5 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene ORF within SC125518 sequence for NM_015878 edited (data generated by NextGen Sequencing)
ATGAAAGGATTTATTGATGATGCAAACTACTCCGTTGGCCTGTTGGATGAAGGAACAAAC CTTGGAAATGTTATTGATAACTATGTTTATGAACATACCCTGACAGGGAAAAATGCATTT TTTGTGGGAGATCTTGGAAAGATTGTGAAGAAACACAGTCAATGGCAGAATGTAGTGGCT CAGATAAAGCCATTCTACACAGTGAAGTGCAACTCTGCTCCAGCTGTACTTGAGATTTTG GCAGCTCTTGGAACCGGATTTGCTTGTTCCAGTAAAAATGAAATGGCTTTAGTGCAAGAG TTGGGTGTACCTCCAGAAAACATTATTTACATAAGTCCTTGCAAGCAAGTGTCTCAGATA AAGTATGCAGCAAAAGTTGGAGTGAATATCCTGACATGTGACAATGAAATTGAATTGAAG AAAATTGCACGTAATCACCCAAATGCCAAGGTCTTACTACATATTGCAACAGAAGATAAT ATTGGAGGTGAAGAGGGTAACATGAAGTTTGGCACTACCCTGAAGAACTGTAGGCATCTC TTGGAATGTGCTAAGGAACTTGATGTCCAAATAATTGGGGTTAAATTTCATGTTTCGAGT GCTTGCAAAGAATCTCAAGTATATGTACATGCTCTATCTGATGCTCGATGTGTGTTTGAC ATGGCTGGAGAAATTGGCTTTACGATGAACATGTTAGACATTGGTGGAGGATTCACGGGA ACTGAATTTCAATTGGAAGAGGTTAATCATGTTATCAGCCCTCTGTTGGATATCTACTTT CCTGAAGGATCTGGTGTTAAGATAATTTCAGAACCCGGAAGCTACTATGTGTCTTCTGCA TTTACACTCGCAGTTAATATCATAGCAAAGAAAGTTGTTGAAAATGATAAATTTCCCTCT GGAGTAGAAAAAACCGGAAGTGATGAACCAGCCTTCATGTATTATATGAATGATGGTGTT TATGGTTCTTTTGCAAGTAAACTGTCTGAGGACTTAAATACCATTCCAGAGGTTCACAAG AAATACAAGGAAGATGAGCCTCTGTTTACAAGCAGCCTTTGGGGTCCATCCTGTGATGAG CTTGATCAAATTGTGGAAAGCTGTCTTCTTCCTGAGCTGAATGTGGGAGATTGGCTTATC TTTGATAACATGGGAGCAGATTCTTTCCATGAACCATCTGCTTTTAATGATTTTCAGAGG CCAGCCATTTATTACATGATGTCATTCAGTGATTGGTATGAGATGCAAGATGCTGGAATT ACTTCAGACTCAATGATGAAGAACTTCTTCTTTGTGCCTTCTTGCATTCAGCTGAGCCAA GAAGACAGCTTTTCCGCTGAAGCTTAA Clone variation with respect to NM_015878.4 >OriGene 5' read for NM_015878 unedited
TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGCGGCCGCAGTTTTT CCTTTTTTCTTCTGCCGTCGCCTTCTCTGCCTCTTCTCATCCTTTCTCGCTCTGCTGCTC TGCAGTGTGACGAGTCCGAATCCTCTTCCCACCCAGCCCGCGCCTTTCTTCTTTTGCCTG CGCTGTTCTATTTCTCCTTCGGCCGCCGCCGCCACTGCTGCACACAGCTGGTGTCGGTGC CGCGCTTTTACCCCCAAGTCGTTCCCGCAGCCTATGGCCCAGGCCGCCTTGGGTATTTCT GCTCAAGGTAACCACATCCCTCTTTAAAAATTCCGCCGAAAAAGAGAAGACGCTTTACCC GACTCTTTGGGCCGTTATCTCACGGCGAACTTTCTGACCAAGTATACAACTACCCAGAGG GCCTAGGAGAAGTGCTGTATAGAGAGCAGTTCGACTTCAACGCTGAGCCACCTTGGGAAC CTAGCTGATGATAGGGGGGTTCCATCTCCCAACTTGTCCATGGAGGTCTTCACTTCAGAA ATCCAAGACTCATATTCATCCAGCTTGGTGTCAAGTGGGCTGTTGCTGCCAGAATTATCT TGTGATTATTTGAGAGATGTATCACGTTCCTTCTGAAGTACAATCAACTGTAGAAGCCTT TGTAGCAGTTTGTTGCATATTCTAAAGACCCAGACATAGGCCTTGGTGGCCCGGCCTCTT GCCTTTTCTGCATTATGACNTTCCGCTTTGTGCAATACGGCTGAAAAGAAAGGATTAATT GATGAAGCAAACCACTCCCGTTGGCCTTGTGGGATGAACGAAACAAACCTTGGGAATGTC ATTGATAACTATGTTTATGAACATACCTTGCACGGAAAAAAGCATTTTTGGGGGAAATCT GGCAACATGGGAAACACCACTCC >OriGene 3' read for NM_015878 unedited
GTAGGCCTTGGCTATGTGCAACTTGCCATGNCCAGGATAGCACTGGGGAAGGGTCACAGG GCTGCCACCCGGGTATCTGTTCAGGAAAACAGCTATGACCGCGGCCGCAATCTAGAGTCG AGTTTTTTTTTTTTTTTTTTTTTTTNTTTTTTAAAATCTACACAAAATTTTATTGCAATC ATACAAGGGTTACATTAGGTCAACAAATACTATGATGCAATTTTACATTTATTAAACTAC AGTTCAAAGCACAAATTTACACATTCTAAATACACTAAACGTTATCTAATGAAGTCACAC TGGTCTTCTAACATTTGATATATCTGGGTGAAAGACATGAACTTTACAAGACTTTAAACA CAAATCCTTAGTATAAAAACTGTGTTCTTGTATGTAAACGATTTAATGGGGAACCCAATT AATGGGCTTCCATCTCCACTAAGTCATCCATTTTGTTGCATATTTTATTTTAAACGCTTA AAGGGTAAGACAAACTGGTAGGTTTAAATCTGGATACATTATCTAAATCTCCCATTATCC CCAATGAATTATAGATGAAAGCTGATTTTGTCTGGTCCCAAATAGCTATTACTAATAGTT TTTGTTGCCAAAAGAATTAAGAGAATAAGATTGTTTAAATTATTTTTCCACACTGGAATG TTGACCAGACAAGCTTAACCTGCAACTTCATATCTAAAGAAGCGTTAATGCCTGTTTAAG CTTCAGCGGAAAAGCTGTCTTCTTGGCTCAGCTGAATGCAAGAAGGCACAAAGAAAAAGT TCTTCATCATTGAGTCTGAAGTAATTCCAGCATCTTGCATCTCATACCAATCACTGAATG ACATCATGTAATAAATGGCTGGCCTCTGAAAATCATAAAAGCAGTGGTTCATGAAAAGAT T |
Restriction Sites | NotI-NotI |
ACCN | NM_015878 |
Insert Size | 2650 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_015878.4, NP_056962.2 |
RefSeq Size | 4348 bp |
RefSeq ORF | 1347 bp |
Locus ID | 51582 |
UniProt ID | O14977 |
Cytogenetics | 8q22.3 |
Domains | Orn_Arg_deC_N |
Protein Families | Druggable Genome |
Gene Summary | The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014] Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform. |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC200022 | AZIN1 (Myc-DDK-tagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 1 |
USD 686.00 |
|
RC200022L1 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, Myc-DDK-tagged |
USD 986.00 |
|
RC200022L2 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, mGFP tagged |
USD 986.00 |
|
RC200022L3 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, Myc-DDK-tagged |
USD 986.00 |
|
RC200022L4 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, mGFP tagged |
USD 986.00 |
|
RG200022 | AZIN1 (tGFP-tagged) - Human antizyme inhibitor 1 (AZIN1), transcript variant 1 |
USD 886.00 |
|
SC324431 | AZIN1 (untagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 1 |
USD 686.00 |
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