Kallikrein 11 (KLK11) (NM_144947) Human Untagged Clone

CAT#: SC125400

KLK11 (untagged)-Human kallikrein-related peptidase 11 (KLK11), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Kallikrein 11
• Synonyms: PRSS20; TLSP
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC125400 sequence for NM_144947 edited (data generated by NextGen Sequencing)
  ATGCAGAGGTTGAGGTGGCTGCGGGACTGGAAGTCATCGGGCAGAGGTCTCACAGCAGCC
  AAGGAACCTGGGGCCCGCTCCTCCCCCCTCCAGGCCATGAGGATTCTGCAGTTAATCCTG
  CTTGCTCTGGCAACAGGGCTTGTAGGGGGAGAGACCAGGATCATCAAGGGGTTCGAGTGC
  AAGCCTCACTCCCAGCCCTGGCAGGCAGCCCTGTTCGAGAAGACGCGGCTACTCTGTGGG
  GCGACGCTCATCGCCCCCAGATGGCTCCTGACAGCAGCCCACTGCCTCAAGCCCCGCTAC
  ATAGTTCACCTGGGGCAGCACAACCTCCAGAAGGAGGAGGGCTGTGAGCAGACCCGGACA
  GCCACTGAGTCCTTCCCCCACCCCGGCTTCAACAACAGCCTCCCCAACAAAGACCACCGC
  AATGACATCATGCTGGTGAAGATGGCATCGCCAGTCTCCATCACCTGGGCTGTGCGACCC
  CTCACCCTCTCCTCACGCTGTGTCACTGCTGGCACCAGCTGCCTCATTTCCGGCTGGGGC
  AGCACGTCCAGCCCCCAGTNACGCCTGCCTCACACCTTGCGATGCGCCAACATCACCATC
  ATTGAGCACCAGAAGTGTGAGAACGCCTACCCCGGCAACATCACAGACACCATGGTGTGT
  GCCAGCGTGCAGGAAGGGGGCAAGGACTCCTGCCAGGGTGACTCCGGGGGCCCTCTGGTC
  TGTAACCAGTCTCTTCAAGGCATTATCTCCTGGGGCCAGGATCCGTGTGCGATCACCCGA
  AAGCCTGGTGTCTACACGAAAGTCTGCAAATATGTGGACTGGATCCAGGAGACGATGAAG
  AACAATTAG
  
  Clone variation with respect to NM_144947.1
  560 t=>n
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_144947 unedited
  GTTANGATATTTGTNATACGACTCACTATAGGCGGCCGCGAAATTCGCACGAGGGCTGGG
  AGAAGCAGGAATCTGCGCTCGGGTTCCGCAGATGCAGAGGTTGAGGTGGCTGCGGGACTG
  GAAGTCATCGGGCAGAGGTCTCACAGCAGCCAAGGAACCTGGGGCCCGCTCCTCCCCCCT
  CCAGGCCATGAGGATTCTGCAGTTAATCCTGCTTGCTCTGGCAACAGGGCTTGTAGGGGG
  AGAGACCAGGATCATCAAGGGGTTCGAGTGCAAGCCTCACTCCCAGCCCTGGCAGGCAGC
  CCTGTTCGAGAAGACGCGGCTACTCTGTGGGGCGACGCTCATCGCCCCCAGATGGCTCCT
  GACAGCAGCCCACTGCCTCAAGCCGTGGGTGCGGGGGCTGGGGCGGTGCCGGGGTGGGGG
  GCTGGGAATGGGGAGATGGATGGAGAGAAGCTCAGGGATACGGGTGCTGGTAAGGGGATC
  ACAGATGGGGATGGGTAGTGTCAGCAACGCTGATGGGCTCGAGCTGGTATTGAAGGTGGG
  GGGATGAATGGGGTTGGGATGGGGCTATGGCTGGGAATGGGGCTACCGTGCGACACGTGG
  AACCAGTCGCACATCCACCGACGTCTCTTCATCCTCAAAGCGTCACTTACTTCTACCACC
  ATGTCTCCCCCGACCTTTTTATTCTGCAATACTGAATCTCCCACCTCAACCGATACATAT
  TTCACCTGGGGAATCCACAATCTCCACAACGATGAAGGGTTGGGATCAAACCCGGACAGA
  CACCTGATACCTTCCCCCCCCCCGGCTTCAACAACAACCTCCCCACCACAAACCACCGAA
  ACGACTATACGCGGGCGAACAGGCATCGCCACACTCCATAACCTGGCCTGCGCCAACTCC
  TCCCCCCTTCTCACCGCGCGCCACTGCTGGCAC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_144947 unedited
  ACTTCCAGGCCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTC
  AGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCAC
  TCATTTAGCAAATATTTATTGAAACCTTGATATATGGCCAGGAGCTGTCTTTGGGGCTGG
  GGATACAACAGAGAACAAACCAGGTGTTGTCATTCCCAGAGTCACAATATTTCAAGGCAG
  AATTTGAATCCAGGTCTCACTGATTTCGAACCCCAGGTTGATTATTAAGTGACAGCATCT
  CCTGTAGTCCAGGAGGCCCAAAGAATGTTCGTAGAGGGTCTTGGCTTAGGGTTTCTTATT
  AACAGAGTGAACAGGAACCAAACACCAAGTGGAAATGGAGGGTGATGGGCTGTGGTGGTG
  GGTCCAGTCTAATTGTTCTTCATCGTCTCCTGGATCCAGTCCACATATTTGCAGACTTTC
  GTGTAGACACCAGGCTTTCGGGTGATCGCACACGGATCCTGGCCCCAGGAGATAATGCCT
  TGAAGAGACTGGTTACAGACCAGAGGGCCCCCGGAGTCACCCTGGCAGGAGTCCTTGCCC
  CCTTCCTGCACGCTGGCACACACCATGGTGTCTGTGATNGTGCCNGGGTTAGCGTTCTTA
  CACTTTCTGTGCTCAAAGATAGGAATGTTGCGCCACCCAAGGTGGGAGGCAAGCTACTGT
  GAAAACAACCTGGAGGGTTTTGGAAAGACCCCCCGGCCCCTTC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_144947
• Insert Size: 2500 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_144947.1, NP_659196.1
• RefSeq Size: 1289 bp
• RefSeq ORF: 849 bp
• Locus ID: 11012
• UniProt ID: Q9UBX7
• Cytogenetics: 19q13.41
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Gene Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
  Transcript Variant: This variant (2) encodes the longest isoform (2) which is preferentially expressed in prostate. This variant represents use of an mammalian interspersed repeat (MIR) alternate promoter and exon sequence. (PMID: 14550626).