Hey L (HEYL) (NM_014571) Human Untagged Clone

CAT#: SC122816

HEYL (untagged)-Human hairy/enhancer-of-split related with YRPW motif-like (HEYL)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Hey L
• Synonyms: bHLHb33; HESR3; HEY3; HRT3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_014571 edited
  ACCAGGCAGCCTGCGTTCGCCATGAAGCGACCCAAGGAGCCGAGCGGCTCCGACGGGGAG
  TCCGACGGACCCATCGACGTGGGCCAAGAGGGCCAGCTGAGCCAGATGGCCAGGCCGCTG
  TCCACCCCCAGCTCTTCGCAGATGCAAGCCAGGAAGAAACGCAGAGGGATCATAGAGAAA
  CGGCGTCGAGACCGCATCAACAGTAGCCTTTCTGAATTGCGACGCTTGGTCCCCACTGCC
  TTTGAGAAACAGGGCTCTTCCAAGCTGGAGAAAGCCGAGGTCTTGCAGATGACGGTGGAT
  CACTTGAAAATGCTCCATGCCACTGGTGGGACAGGATTCTTTGATGCCCGAGCCCTGGCA
  GTTGACTTCCGGAGCATTGGTTTTCGGGAGTGCCTCACTGAGGTCATCAGGTACCTGGGG
  GTCCTTGAAGGGCCCAGCAGCCGTGCAGACCCCGTCCGGATTCGCCTTCTCTCCCACCTC
  AACAGCTACGCAGCCGAGATGGAGCCTTCGCCCACGCCCACTGGCCCTTTGGCCTTCCCT
  GCCTGGCCCTGGTCTTTCTTCCATAGCTGTCCAGGGCTGCCAGCCCTGAGCAACCAGCTC
  GCCATCCTGGGAAGAGTGCCCAGCCCTGTCCTCCCCGGTGTCTCCTCTCCTGCTTACCCC
  ATCCCAGCCCTCCGAACCGCTCCCCTTCGCAGAGCCACAGGCATCATCCTGCCAGCCCGG
  AGGAATGTGCTGCCCAGTCGAGGGGCATCTTCCACCCGGAGGGCCCGCCCCCTAGAGAGG
  CCAGCGACCCCTGTGCCTGTCGCCCCCAGCAGCAGGGCTGCCAGGAGCAGCCACATCGCT
  CCCCTCCTGCAGTCTTCCTCCCCAACACCCCCTGGTCCTACAGGGTCGGCTGCTTACGTG
  GCTGTTCCCACCCCCAACTCATCCTCCCCAGGGCCAGCTGGGAGGCCAGCGGGAGCCATG
  CTCTACCACTCCTGGGTCTCTGAAATCACTGAAATCGGGGCTTTCTGAGCTGCCCCTTCA
  CCACCCCGCCCCAAGGAATAAGGAAGGTTCTTTTACCAGGAGCCCAAAAAAGGGCACTGC
  CTTTTCTGCTTTGCTTCGTGGACTGGCTCATATGTGAAGGCACGTTCTCCAGCCATCAGA
  GGCCCCCTCCTCCTCCAACCCATCTCTCCTTCTCACTGTTATCCCAGCTTATCCACCCAG
  CTCTCCTGGAGCTGTTCTGGTCTCAGAGGCTTGGTTCCATTTCTCACCTGAACAGATGAG
  TCCTGGGAGAGACCCTCAGAGATCCGCCCAGACCCCTCTCCTGCCCTCTGCACACCAGCA
  GCAGGCATGAACCTTGGGTCTGGGAAAAAGCTTTAACCTGCAGGGCACCAGGACCCAAGG
  CAGGCTGTTCCTTGGGGCGGTCAGACCCCAGTCAGGAGCAATGACTGACTGGCTGCAGCC
  TTCCCACGCCAAGAGGCTGGAACATAGTGTCTGCCTCGCTTCCTGGAGATAGTAACTGAG
  CAGGGGCTACAAAGAGGTCTCCTGGGAACCCTGTCTGCCCCTTCCCACCTGTCCTTGGGC
  CACACCATCACACTGAACCACAGGACAGACCCTTTCTCCACCACAGCCAAGGCCTGGAGA
  CTGGGGGCCCAGCAGAGCCTGCTCCCACCCTCCTCCCAGCAGCAGACACCCACCCTCTCA
  CTGACTAACAGGTCCCTGCACACAGCTGGCCTGGTAAACCCAGCTGGGAGGTTTCTAGGC
  AGCAGCAAAACTCTGTGACAGGGTGTCCTCACACCAGGCCTTGGACAGCTCTCCCAGACA
  GGAGCCAGGGTTGAGCAATGGAGAGCCCAGCCCCCACGTCTTACAGTCGCCATCCTCCAG
  GCGTGTGGTCCCTCCCCATTGGGTGCACAGTGCAGAGGGGCCGTGGCCCCATGTGATGGT
  GCGCAGAGAGGAACCTCTTGGGATTCAGCACCAGACGTCTGTGCTGCCTGGTTTGCATCC
  GGCTCACAGAGCCCAGACTGCTGGAACAGCCAAGGACTGTCAGGCTGGACAAAAATAACT
  GCAAGGAGGGGCAAGAGAAAGGATGATTCGAGGCACCTTGGCCCTTCAAGGTCATGCAGT
  GGGTCGAGCGCCTGAGATCCTGTTCACCAGGACTCCACAGAGCTGGCTCTGCTCAGAAGC
  CATTTCATTCCCCGGCTCCACCCTAGGCCACTTTTTCTAACAGAGGAAACAAATGGTCCA
  GCAGTCGTTCCCAGCAGAACAGCGGAGCCTGGACTGACACCCAGTGGGACCAGTGTTGCC
  ACACCAGTTGATAAAATGCAGAAACCCTTCTGTACTCGTTGGTAAATATCTACTCCCCCA
  AGTGACTCCAGGTGCCCCCCACCGCCTGGCACTTCCCCCAGGACTCCTACGATCTGGTTA
  CTGCCTGGCCGATCCAAGGCTGTGGAGTCCCAGAGCCAGCAGTTCACTGGTGCTCATTCC
  ACACTGGTTAGATACTTCAGTTGTCACCCCTGGGAAGATTCTCCCACCTCCTCCCTTTGA
  TGGAACCACCCTCCCCAGAGGCTGCATTGAGGAGACTCCACAGACTGAAAAGTGAGTTTG
  CAGAAACCTTGGGGAAAAGGGCCCTTTCAAAGAAGTGGATAAGAGGGAGGAGATCATTGA
  GTGACCCAGAAAGCTCTTTTGAAAAGACAGACTCCTCAAGGAGAGATAAAGAGGAAAGCA
  CCTCTTTCATTTTTTAGTGTGAGCTAATTCCATCAGACTGCTGTCCTCCTGGACCCATCT
  GAGATGTGCAGTAGCAAGGAGAGGGGGGATCATTTTAGAGAGTGGGTCATTGGCAGGGAG
  TGCTCCGGAGGGAGGCAGAGGGGAGACTGTGGTAGAAGGAAGACAGAACTCACACATGCT
  CCCAGGATTGGGGACAGGGACAGAGGAGGTAACAGAAGGCAAAGGCCAGTTTCCCCGTTA
  TCATGAAGGGGCCCACTCAGGACAGGAACAAGGACAACTCCTCCTCCTCCTCCTCCTCTC
  CTGCTGCTCCTGGGATACCAGGTCAGTGATGTAGTCTTGCAGTTTGGCAACTTCCTAGCC
  TGAGAATCCCTAGTGGGGCTGTGGGAAACACATTTCCACGTTGCAAGCATGCAACTCCAA
  AGAATCTGTGATGCCACTGAAATGAGATGGGAATGATCCAGCTCTTTCAGCATCTTGGTT
  GAACTTGCTTTCATTGTCCCTGGGATATTGTGGAAGGAAAGGTGACTGTGTGATCTGATT
  CTGTGGTCAAGGACTTGCATCTTGTGTTTCTATCCCCAAGCCTTCCTGGTGTCTCCAACT
  CCTACCCCATTGCATGGGTTGTTGCGGACATCCAATAAAGATTTTTTTAGTGCTTCTGGA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014571 unedited
  GGAAGCGGTCATATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGACCA
  GGCAGCCTGCGTTCGCCATGAAGCGACCCAAGGAGCCGAGCGGCTCCGACGGGGAGTCCG
  ACGGACCCATCGACGTGGGCCAAGAGGGCCAGCTGAGCCAGATGGCCAGGCCGCTGTCCA
  CCCCCAGCTCTTCGCAGATGCAAGCCAGGAAGAAACGCAGAGGGATCATAGAGAAACGGC
  GTCGAGACCGCATCAACAGTAGCCTTTCTGAATTGCGACGCTTGGTCCCCACTGCCTTTG
  AGAAACAGGGCTCTTCCAAGCTGGAGAAAGCCGAGGTCTTGCAGATGACGGTGGATCACT
  TGAAAATGCTCCATGCCACTGGTGGGACAGGATTCTTTGATGCCCGAGCCCTGGCAGTTG
  ACTTCCGGAGCATTGGTTTTCGGGAGTGCCTCACTGAGGTCATCAGGTACCTGGGGGTCC
  TTGAAGGGCCCAGCAGCCGTGCAGACCCCGTCCGGATTCGCCTTCTCTCCCACCTCAACA
  GCTACGCAGCCGAGATGGAGCCTTCGCCCACGCCCACTGGCCCTTTGGCCTTCCCTGCCT
  GGCCCTGGTCTTTCTTCCATAGCTGTCCAGGGCTGCCAGCCCTGAGCAACCAGCTCGCCA
  TCCTGGGAAGAGTGCCCAGCCCTGTCCTCCCCGGTGTCTCCTCTCCTGCTTACCCCATCC
  CAGCCCTCCGAACCGCTCCCCTTCGCAGAGCCACAGGCATCATCCTGCCAGCCCCGGAGA
  ATGTGCTGCCCAGTCGAGGGGCATCTTCCACCCCGGAGGCCCGNCCCCTAGAGAGGCAGC
  GACCCCTGTGCCTGTCGCCCCCAGCAGCAGGGCTGCCAGNAGCAGACACATCGCTCCCCC
  TCCTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014571 unedited
  GGGGTTTTGCCTAAAAAAACTTATGGAGTCCCACAACCCAGCAAGGGGTAGGAGTTGNGA
  AACACCAGNAAGGCTTGGGGNATAGNAAACACAANATGCAAGTCCTTGACCACANAATCA
  GATCACACAGTCACCTTTCCTTCCACAATATCCCAGGGACAATGAAAGCAAGTTCAACCA
  AGATGCTGAAAGAGCTGGATCATTCCCATCTCATTTCAGTGGCATCACAGATTCTTTGGA
  GTTGCATGCTTGCAACGTGGAAATGTGTTTCCCACAGCCCAGCTAGGGATTCTCAGGCTA
  GGAAGTTGCCAAACTGCAAGACTACATCACTGACCTGGTATCCCAGGAGCAGCAGGAGAG
  GAGGAGGAGGAGGAGGAGTTGTCCTTGTTCCTGTCCTGAGTGGGCCCCTTCATGATAACG
  GGGAAACTGGCCTTTGCCTTCTGTTACCTCCTCTGTCCCTGTCCCCAATCCTGGGAGCAT
  GTGTGAGTTCTAGTCTTCCTTCTACCACAGTCTCCCCTCTGCCTCCCTCCGGAGCACTCC
  CTGCCAATGACCCACTCTCTAAAATGATCCCCCCTCTCCTTGCTACTGCACATCAGAGAT
  GGGTCCAGGAGGACAGCAGTCTGATGGAATTAGCTCACACTAAAAAATGAAAGAGGTGCT
  TTCCTCTTTATCTCTCCTTGAGGAGTCTGTCTTTTCAAAAGAGCTTTCTGGGTCACTCAA
  TGATCTCCTCCCTCTTATCCACTTCTTTGAAAGGGCCCTTTTCCCCAAGGGTTCTGCAAA
  CTTACTTTTCAGTCTGTGGAGTCCTCTCAATGGCAGCTCTGGGGAGGGGGGGTCCATCAA
  AGGGAGGGAGGTGGAGAATCTTTCCCGGGGGGACCACTGGAATTCTCTACCGGGGG
  
• Restriction Sites: Please inquire
• ACCN: NM_014571
• Insert Size: 3416 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_014571.2, NP_055386.1
• RefSeq Size: 3416 bp
• RefSeq ORF: 987 bp
• Locus ID: 26508
• UniProt ID: Q9NQ87
• Cytogenetics: 1p34.2
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]