RANK (TNFRSF11A) (NM_003839) Human Untagged Clone

CAT#: SC117707

TNFRSF11A (untagged)-Human tumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RANK
• Synonyms: CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCE-R; TRANCER
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003839 edited
  ATGGCCCCGCGCGCCCGGCGGCGCCGCCCGCTGTTCGCGCTGCTGCTGCTCTGCGCGCTG
  CTCGCCCGGCTGCAGGTGGCTTTGCAGATCGCTCCTCCATGTACCAGTGAGAAGCATTAT
  GAGCATCTGGGACGGTGCTGTAACAAATGTGAACCAGGAAAGTACATGTCTTCTAAATGC
  ACTACTACCTCTGACAGTGTATGTCTGCCCTGTGGCCCGGATGAATACTTGGATAGCTGG
  AATGAAGAAGATAAATGCTTGCTGCATAAAGTTTGTGATACAGGCAAGGCCCTGGTGGCC
  GTGGTCGCCGGCAACAGCACGACCCCCCGGCGCTGCGCGTGCACGGCTGGGTACCACTGG
  AGCCAGGACTGCGAGTGCTGCCGCCGCAACACCGAGTGCGCGCCGGGCCTGGGCGCCCAG
  CACCCGTTGCAGCTCAACAAGGACACAGTGTGCAAACCTTGCCTTGCAGGCTACTTCTCT
  GATGCCTTTTCCTCCACGGACAAATGCAGACCCTGGACCAACTGTACCTTCCTTGGAAAG
  AGAGTAGAACATCATGGGACAGAGAAATCCGATGCGGTTTGCAGTTCTTCTCTGCCAGCT
  AGAAAACCACCAAATGAACCCCATGTTTACTTGCCCGGTTTAATAATTCTGCTTCTCTTC
  GCGTCTGTGGCCCTGGTGGCTGCCATCATCTTTGGCGTTTGCTATAGGAAAAAAGGGAAA
  GCACTCACAGCTAATTTGTGGCACTGGATCAATGAGGCTTGTGGCCGCCTAAGTGGAGAT
  AAGGAGTCCTCAGGTGACAGTTGTGTCAGTACACACACGGCAAACTTTGGTCAGCAGGGA
  GCATGTGAAGGTGTCTTACTGCTGACTCTGGAGGAGAAGACATTTCCAGAAGATATGTGC
  TACCCAGATCAAGGTGGTGTCTGTCAGGGCACATGTGTAGGAGGTGGTCCCTACGCACAA
  GGCGAAGATGCCAGGATGCTCTCATTGGTCAGCAAGACCGAGATAGAGGAAGACAGCTTC
  AGACAGATGCCCACAGAAGATGAATACATGGACAGGCCCTCCCAGCCCACAGACCAGTTA
  CTGTTCCTCACTGAGCCTGGAAGCAAATCCACACCTCCTTTCTCTGAACCCCTGGAGGTG
  GGGGAGAATGACAGTTTAAGCCAGTGCTTCACGGGGACACAGAGCACAGTGGGTTCAGAA
  AGCTGCAACTGCACTGAGCCCCTGTGCAGGACTGATTGGACTCCCATGTCCTCTGAAAAC
  TACTTGCAAAAAGAGGTGGACAGTGGCCATTGCCCGCACTGGGCAGCCAGCCCCAGCCCC
  AACTGGGCAGATGTCTGCACAGGCTGCCGGAACCCTCCTGGGGAGGACTGTGAACCCCTC
  GTGGGTTCCCCAAAACGTGGACCCTTGCCCCAGTGCGCCTATGGCATGGGCCTTCCCCCT
  GAAGAAGAAGCCAGCAGGACGGAGGCCAGAGACCAGCCCGAGGATGGGGCTGATGGGAGG
  CTCCCAAGCTCAGCGAGGGCAGGTGCCGGGTCTGGAAGCTCCCCTGGTGGCCAGTCCCCT
  GCATCTGGAAATGTGACTGGAAACAGTAACTCCACGTTCATCTCCAGCGGGCAGGTGATG
  AACTTCAAGGGCGACATCATCGTGGTCTACGTCAGCCAGACCTCGCAGGAGGGCGCGGCG
  GCGGCTGCGGAGCCCATGGGCCGCCCGGTGCAGGAGGAGACCCTGGCGCGCCGAGACTCC
  TTCGCGGGGAACGGCCCGCGCTTCCCGGACCCGTGCGGCGGCCCCGAGGGGCTGCGGGAG
  CCGGAGAAGGCCTCGAGGCCGGTGCAGGAGCAAGGCGGGGCCAAGGCTTGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003839 unedited
  AACCCCGCCCGTTGCCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAG
  AGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAA
  TTCGGCACGAGGCCGCGGCGCCCGCCAGCCTGTCCCGCGCCATGGCCCCGCGCGCCCGGC
  GGCGCCGCCCGCTGTTCGCGCTGCTGCTGCTCTGCGCGCTGCTCGCCCGGCTGCAGGTGG
  CTTTGCAGATCGCTCCTCCATGTACCAGTGAGAAGCATTATGAGCATCTGGGACGGTGCT
  GTAACAAATGTGAACCAGGAAAGTACATGTCTTCTAAATGCACTACTACCTCTGACAGTG
  TATGTCTGCCCTGTGGCCCGGATGAATACTTGGATAGCTGGAATGAAGAAGATAAATGCT
  TGCTGCATAAAGTTTGTGATACAGGCAAGGCCCTGGTGGCCGTGGTCGCCGGCAACAGCA
  CGACCCCCCGGCGCTGCGCGTGCACGGCTGGGTACCACTGGAGCCAGGACTGCGAGTGCT
  GCCGCCGCAACACCGAGTGCGCGCCGGGCCTGNGCGCNCAGCACCCGTTGCAGCTCAACA
  GGNACACAGTGTGCANACCTTGCCTTGCANGCTACTTCTCTGATGCCTTTTCTNCACGGA
  CAAATGCAGACCCTGGACCAACTGTACCTTNCTTGGNAAGAGAGTAGAACATCATGGGAC
  AGAGAAATCCGATGCNGTTTGCAGTTCTTCTCTGCCAGCTAGAAAACCACCAATGAACCC
  CATGTTACTTGCCCGGTTTAATAATTCTGCTTCTCTTCCCGTCTGGTGCCCTGGTGGCTG
  GCATCATCTTTGGCGTTTGCTTTAGAAAAAAAGGAAAGCACTCCAGCTAATTTGGGCACT
  GGATCAATGAGCTTGGGGGCCGCTAAGTGAAATAAGAGTCCTCAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003839 unedited
  NNCCCCGCTATCGCTATGNNACCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTTTTCGGGTTTCCTTTTTTCTTTCTTTTAGAAAAA
  TGAGAATATAGAACATTTTTCAGAATATGAAAGTCCCACCACATGTTCCTAGCAACTTAA
  CAACTATCTCCAGGCCTCACATGTTTAGCCCTTTCCCAAAAGTGTTTACAATGAACACAC
  CCTGGGAAAGCCATCTCTAAAACACTGGGAGCAGGGGCACAAAAAAAAATACCTAAAGCA
  GGCCCGCGGGGGGGCTCACCCCTGTAATCCCAGTACTTTGGGAGGCCCAGGCTGGAGGAC
  TGCTTTACCTGGGGAGTTTGAGACCCGGCTGGGTAACATGGGGGGACCGGGTCTCTGGGG
  GGGGAGTCCGGGGGAGGAAACTGGGCGTGGCCCGCAGCTGGGATCCCACCTACTTCCGAA
  GGGGGGGGGGGAGGATCACTTTGGTTGGTTGAGCCCCAGTTGGTCAAAAAAGGAGAACAA
  AAGGGGAAGAGCAAAAGAAGGGACCCTCCCCTTTTGGGAAAATTTTGAAAAAACCCTTTC
  TTTAAAAAAGGAGGGGCGAAAGAATTTCAGAAAAGCTCTCTAAAGGAATCACAAATTGGG
  GGGGGAAAAAAAAACCCCCCCCCCCCAAAAAAAAGGCGAGTCCCTATAAAATCGGTGGTC
  TTATTGCCCACAATTAATCGGTGGAGATCTGTGAGGGGGGGGTGGAGGGAACATTGGCCT
  AAGGGTGGGGGGGTGTGCTTTCAACCCCGGGGTTGGGGGACTCTCTTCCCCTTATTCTTC
  TTTTGTAAAACCTATTTTCTGGTGCGGCGGAGGGGGGCGCAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003839
• Insert Size: 2900 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003839.2, NP_003830.1
• RefSeq Size: 3133 bp
• RefSeq ORF: 1851 bp
• Locus ID: 8792
• UniProt ID: Q9Y6Q6
• Cytogenetics: 18q21.33
• Domains: TNFR
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction
• Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).