Sigirr (NM_001024887) Rat Tagged ORF Clone
CAT#: RR203114
- TrueORF®
Sigirr (Myc-DDK-tagged ORF) - Rat single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), (10 ug)
Lentiviral Particles: DDK w/ Puro mGFP w/ Puro
"NM_001024887" in other vectors (3)
Specifications
Product Data | |
Type | Rat Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | Sigirr |
Synonyms | RGD1306732 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RR203114 representing NM_001024887
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCAGGTGTCTGTGACAGGGTCCCTAATTTCCTTTCCCCATCTGAAGACCAAGCCCTGGGACCTGCCC TTGGCAGTGCAGTTGCTTTGAATTGCACAGCTTGGGTGTTCTCTAGGCCCCAGTGTCCCCAGCCATCAGT ACAATGGCTAAAAGATGGTCTGGCATTGGGCAATGGAAGCCACTTCAGCCTCCATCAAGACTTCTGGGTC AGTGACAACTTCTCGGAGATTGTGTCCAGTGTTCTGGTGTTCAACTTGACCAAAGCTGAGGACTATGGAA CCTTCACTTGTTCTGCCTGGAACGTCAGCTCCCACTCCTTCACTCTCTGGCGAGCTGGCCCTGCCGGCCA TGTGGCTGCGGTGCTGGCTTCCCTCCTTGTCCTAGTGGTTCTGCTGCTGGTGGCCCTTCTCTATGTTAAG TGTCGTCTGAACGTGCTGCTTTGGTACCAAGACACTTACGGGGAGGTAGAGATGAATGATGGGAAGTTAT ACGATGCGTACGTGTCCTATAGCGACCGCCCAGAGGACCGCAAATTTGTAAATTTTATTCTGAAGCCTCA GTTGGAGCGGCGTCGGGGATACAAGCTCTTCCTAGAGGACCGCGACCTCTTGCCGCGAGCGGAGCCCTCT GCCGACCTTTTGGTGAACCTGAGTCGCTGTCGGCGTCTCATCGTGGTTCTTTCAGATGCCTTCCTCAGAC GTCCCTGGTGTAGCCAGAGCTTCCGGGAGGGACTGTGCCGCCTACTGGAGCTCACCCGCAGACCTATCTT TATCACCTTCGAGGGCCAGAGGCGTGAGCCCATTCACCCTGCTCTCCGTCTCCTGCGCCAGCACCGCCAC CTCGTGACCCTGCTGCTTTGGAAGCCTGGCTCCGTGACACCTTCCTCTGATTTTTGGAAAGAGCTACAGT TGGCACTACCACGGAAGGTGCAATACAGACCCGTGGAGGGAGACCCCCAAACCCGACTTCAGGATGACAA AGATCCCATGCTAATCGTGAGAGGACGTGCTGCCCAGGGCCGGGCCATGGAGTCAGAGCTGGATCCAGAC CCTGAGGGAGACCTGGGTGTCCGTGGACCTGTCTTTGGGGAGCCACCAACTCCACTACACGAAAGCAAGG TCTCCATAGGAGAGGGCCATGCCAGTGAAATGGATGTCTCTGACCTTGGCTCTCGAAACTACAGTGCGCG AACAGACTTCTACTGCCTTGTGTCTGAGGATGACGTG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RR203114 representing NM_001024887
Red=Cloning site Green=Tags(s) MAGVCDRVPNFLSPSEDQALGPALGSAVALNCTAWVFSRPQCPQPSVQWLKDGLALGNGSHFSLHQDFWV SDNFSEIVSSVLVFNLTKAEDYGTFTCSAWNVSSHSFTLWRAGPAGHVAAVLASLLVLVVLLLVALLYVK CRLNVLLWYQDTYGEVEMNDGKLYDAYVSYSDRPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPS ADLLVNLSRCRRLIVVLSDAFLRRPWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLRQHRH LVTLLLWKPGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRAMESELDPD PEGDLGVRGPVFGEPPTPLHESKVSIGEGHASEMDVSDLGSRNYSARTDFYCLVSEDDV TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | NM_001024887 |
ORF Size | 1227 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001024887.1, NP_001020058.1 |
RefSeq Size | 1634 bp |
RefSeq ORF | 1230 bp |
Locus ID | 309106 |
UniProt ID | Q4V892 |
Cytogenetics | 1q41 |
MW | 46.2 kDa |
Gene Summary | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RN203114 | Sigirr (untagged ORF) - Rat single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), (10 ug) |
USD 503.00 |
|
RR203114L3 | Lenti ORF clone of Sigirr (Myc-DDK-tagged ORF) - Rat single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), (10 ug) |
USD 803.00 |
|
RR203114L4 | Lenti ORF clone of Sigirr (mGFP-tagged ORF) - Rat single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), (10 ug) |
USD 803.00 |
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