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XRN1 (NM_019001) Human Tagged ORF Clone
CAT#: RG221062
- TrueORF®
XRN1 (tGFP-tagged) - Human 5'-3' exoribonuclease 1 (XRN1), transcript variant 1
ORF Plasmid: DDK
"NM_019001" in other vectors (2)
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Other products for "XRN1"
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | TurboGFP |
| Symbol | XRN1 |
| Synonyms | SEP1 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG221062 representing NM_019001
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGC ATCAGATTCCTGAATTTGACAACTTGTACCTGGATATGAATGGAATTATACATCAGTGCTCCCATCCTAA TGGTGATGATGTTCACTTTAGAATTTCAGATGATAAAATCTTTACTGATATTTTTCACTACCTGGAGGTG TTGTTTCGCATTATTAAACCCAGGAAAGTGTTCTTTATGGCTGTAGATGGTGTGGCTCCTCGAGCAAAAA TGAACCAGCAGCGTGGGAGGCGTTTTAGGTCAGCAAAGGAGGCAGAAGACAAAATTAAAAAGGCAATAGA GAAGGGAGAAACTCTTCCTACAGAGGCCAGATTTGATTCCAACTGTATCACACCAGGAACTGAATTTATG GCCAGGTTACATGAACATCTGAAGTATTTTGTAAATATGAAAATTTCCACAGACAAGTCATGGCAAGGAG TTACCATCTACTTCTCAGGCCATGAGACTCCTGGAGAAGGAGAGCATAAAATCATGGAATTTATCAGATC CGAGAAAGCAAAGCCAGATCATGATCCAAACACCAGACACTGTCTTTATGGTTTAGATGCTGACTTGATT ATGCTTGGATTAACAAGTCATGAGGCACATTTTTCTCTCTTAAGAGAAGAAGTTCGATTTGGTGGCAAAA AAACACAACGGGTATGTGCTCCAGAAGAAACTACATTTCACCTTCTACACTTGTCTTTAATGAGAGAGTA TATTGACTATGAGTTTTCAGTATTAAAAGAAAAGATCACATTTAAATATGATATTGAAAGGATAATAGAT GATTGGATTTTGATGGGGTTTCTTGTTGGTAATGATTTTATCCCTCATCTACCTCATTTACATATTAATC ATGATGCACTGCCTCTTCTTTATGGAACATATGTTACCATCCTGCCAGAACTTGGGGGTTATATTAATGA AAGTGGGCACCTCAACTTACCTCGATTTGAGAAATACCTTGTGAAACTATCAGATTTTGATCGGGAGCAC TTCAGTGAAGTTTTTGTGGACCTAAAATGGTTTGAAAGCAAAGTTGGTAACAAGTACCTCAATGAAGCAG CAGGTGTCGCAGCAGAAGAAGCCAGGAACTACAAGGAAAAGAAAAAGTTAAAGGGCCAGGAAAATTCTCT GTGTTGGACTGCTTTAGACAAAAATGAAGGCGAAATGATAACTTCTAAGGATAATTTAGAAGATGAGACT GAAGATGATGACCTATTTGAAACTGAGTTTAGACAATATAAAAGAACATATTACATGACGAAGATGGGGG TTGACGTAGTATCTGATGACTTTCTGGCTGATCAAGCTGCATGTTATGTTCAGGCAATACAGTGGATTTT GCACTATTACTATCATGGAGTTCAGTCCTGGAGCTGGTATTATCCTTATCATTATGCACCTTTCCTGTCT GATATACACAACATCAGTACACTCAAAATCCATTTTGAACTAGGAAAACCTTTTAAGCCATTTGAACAGC TTCTTGCTGTACTTCCAGCAGCCAGCAAAAATTTACTTCCTGCATGCTACCAGCATTTGATGACCAATGA AGACTCACCAATTATAGAATATTACCCACCTGATTTTAAAACTGACCTAAATGGGAAACAACAGGAATGG GAAGCTGTGGTGTTAATCCCTTTTATTGATGAGAAGCGATTATTGGAAGCCATGGAGACATGTAACCACT CCCTCAAAAAGGAAGAGAGGAAAAGAAACCAACATAGTGAGTGCCTAATGTGCTGGTATGATAGAGACAC AGAGTTTATCTATCCTTCTCCATGGCCAGAAAAGTTCCCTGCCATAGAACGATGTTGTACAAGGTATAAA ATAATATCCTTAGATGCTTGGCGTGTAGACATAAACAAAAACAAAATAACCAGAATTGACCAGAAAGCAT TATATTTCTGTGGATTTCCTACTCTGAAACACATCAGACACAAATTTTTTTTGAAGAAAAGTGGTGTTCA AGTATTCCAGCAAAGCAGTCGTGGAGAAAACATGATGTTGGAAATCTTAGTGGATGCAGAATCAGATGAA CTTACCGTAGAAAATGTAGCTTCATCAGTGCTTGGAAAATCTGTCTTTGTTAATTGGCCTCACATTGAGG AAGCTAGAGTCGTGGCTGTATCAGATGGAGAAACTAAGTTTTACTTGGAAGAACCTCCAGGAACACAGAA GCTTTATTCAGGAAGAACTGCCCCACCATCTAAAGTGGTTCATCTTGGAGATAAAGAACAATCTAACTGG GCAAAAGAAGTACAAGGAATTTCAGAACACTACCTGAGAAGAAAAGGAATAATAATAAATGAAACATCTG CAGTTGTGTATGCTCAGTTACTCACAGGTCGTAAATATCAAATAAATCAAAATGGTGAAGTTCGTCTAGA GAAACAGTGGTCAAAACAAGTTGTTCCTTTTGTTTATCAAACTATTGTCAAGGACATCCGAGCTTTCGAC TCCCGTTTCTCCAATATCAAAACATTGGATGATTTGTTTCCTCTGAGAAGTATGGTCTTTATGCTGGGAA CTCCCTATTATGGCTGCACTGGAGAAGTTCAGGATTCAGGTGATGTGATTACAGAAGGTAGGATTCGTGT GATTTTCAGCATTCCATGTGAACCCAATCTTGATGCTTTAATACAGAACCAGCATAAATATTCTATAAAG TACAACCCAGGATATGTGTTGGCCAGTCGCCTTGGAGTGAGTGGATACCTTGTTTCAAGGTTTACAGGAA GTATTTTTATTGGAAGAGGATCTAGGAGAAACCCTCATGGAGACCATAAAGCAAATGTGGGTTTAAATCT CAAATTCAACAAGAAAAATGAGGAGGTACCTGGATATACTAAGAAAGTTGGAAGTGAATGGATGTATTCA TCTGCAGCAGAACAACTTCTGGCAGAGTACTTAGAGAGAGCTCCAGAACTATTTAGTTATATAGCCAAAA ATAGCCAAGAGGATGTGTTCTATGAAGATGACATTTGGCCTGGAGAAAATGAGAATGGTGCTGAAAAAGT TCAAGAAATTATTACTTGGCTAAAAGGACATCCTGTCAGTACTTTATCTCGTTCTTCTTGTGATTTACAA ATTCTGGATGCAGCTATTGTTGAGAAAATTGAGGAAGAAGTCGAAAAGTGCAAGCAAAGAAAGAATAATA AGAAGGTGCGAGTAACAGTGAAACCCCATTTGCTATACAGACCTTTAGAACAGCAACATGGAGTCATTCC TGATCGGGATGCAGAATTTTGTCTTTTTGACCGTGTTGTAAATGTGAGAGAAAACTTCTCAGTTCCAGTT GGCCTTCGAGGCACCATCATAGGAATAAAAGGAGCTAATAGAGAAGCCGATGTACTATTTGAAGTATTAT TTGATGAAGAATTTCCTGGAGGGTTAACAATAAGATGCTCACCTGGTAGAGGTTATCGACTGCCAACAAG TGCCTTGGTGAACCTTTCTCATGGGAGTCGCTCTGAAACTGGAAATCAGAAGTTGACAGCCATCGTAAAA CCACAACCAGCTGTACATCAACATAGCTCAAGTTCATCAGTTTCCTCTGGGCATTTGGGAGCCCTCAACC ATTCCCCTCAATCACTTTTTGTTCCTACTCAAGTACCTACTAAAGATGATGATGAATTCTGCAACATTTG GCAGTCCTTACAGGGATCTGGAAAGATGCAATACTTTCAGCCAACTATACAAGAGAAGGGTGCAGTTCTA CCTCAAGAAATAAGCCAAGTAAATCAACATCATAAATCTGGCTTTAATGACAACAGTGTTAAATATCAGC AAAGAAAACATGACCCTCACAGAAAATTTAAAGAAGAGTGTAAGAGTCCTAAAGCTGAGTGTTGGTCCCA AAAAATGTCCAATAAGCAGCCTAACTCTGGAATTGAGAACTTTTTAGCATCTTTGAATATCTCCAAAGAA AATGAAGTACAGTCATCTCATCATGGGGAGCCTCCAAGTGAAGAGCATTTGTCACCACAGTCATTTGCCA TGGGAACACGGATGCTTAAAGAAATTCTAAAAATTGATGGCTCTAACACTGTGGACCATAAGAATGAAAT CAAACAGATTGCTAATGAAATCCCTGTTTCCTCTAACAGAAGAGATGAATATGGATTACCCTCTCAGCCT AAACAAAATAAGAAATTAGCATCTTATATGAACAAGCCTCACAGTGCTAATGAGTACCATAATGTTCAGT CTATGGACAATATGTGTTGGCCTGCCCCCAGCCAGATCCCTCCTGTATCCACACCAGTAACTGAACTTTC TCGAATTTGTTCCCTTGTTGGAATGCCACAACCTGATTTCTCCTTTTTTAGGATGCCACAGACAATGACC GTTTGCCAAGTAAAATTATCTAATGGCTTACTGGTACATGGGCCACAGTGCCACTCTGAAAATGAAGCCA AAGAGAAAGCTGCACTTTTTGCTTTACAACAGTTGGGCTCCTTAGGCATGAATTTCCCTTTGCCTTCACA AGTATTTGCAAATTATCCTTCAGCTGTACCACCTGGAACCATTCCTCCAGCCTTTCCCCCACCTACTGGC TGGGATCACTATGGAAGCAACTATGCATTGGGGGCAGCTAATATAATGCCTTCGTCGTCTCATCTCTTTG GCTCAATGCCATGGGGACCATCGGTGCCAGTTCCTGGGAAGCCCTTCCATCATACTTTATATTCTGGGAC CATGCCCATGGCTGGGGGAATACCAGGGGGTGTGCACAATCAGTTTATACCTCTGCAGGTTACTAAAAAA AGGGTTGCAAACAAAAAGAACTTTGAGAATAAGGAAGCCCAGAGTTCTCAAGCCACTCCAGTTCAGACTA GCCAGCCAGATTCTTCCAACATTGTCAAAGTAAGTCCACGGGAGAGCTCATCAGCTTCTTTGAAGTCCTC TCCGATTGCTCAACCTGCATCTTCTTTTCAAGTTGAAACTGCCTCTCAAGGCCATAGTATATCTCACCAT AAGTCAACACCAATCTCTTCTTCAAGAAGAAAATCAAGAAAACTGGCTGTTAATTTTGGTGTTTCTAAAC CTTCTGAG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >RG221062 representing NM_019001
Red=Cloning site Green=Tags(s) MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNGDDVHFRISDDKIFTDIFHYLEV LFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFM ARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLI MLGLTSHEAHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIID DWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREH FSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDET EDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLS DIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEW EAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYK IISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDE LTVENVASSVLGKSVFVNWPHIEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNW AKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFD SRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIK YNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYS SAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQ ILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPV GLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVK PQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVL PQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLNISKE NEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQP KQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFFRMPQTMT VCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTG WDHYGSNYALGAANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKK RVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHH KSTPISSSRRKSRKLAVNFGVSKPSE TRTRPLE - GFP Tag - V |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_019001 |
| ORF Size | 5118 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_019001.2, NP_061874.2 |
| RefSeq Size | 10123 bp |
| RefSeq ORF | 5121 bp |
| Locus ID | 54464 |
| UniProt ID | Q8IZH2 |
| Cytogenetics | 3q23 |
| Protein Pathways | RNA degradation |
| Gene Summary | This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
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