Pim3 (NM_145478) Mouse Untagged Clone

CAT#: MC205349

Pim3 (untagged) - Mouse proviral integration site 3 (Pim3), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Pim3
• Synonyms: BC026639; Kid1
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC017621
  GCAGGGCGGGTGAGAGCGCCGTGAAAGCCGCGGAACGCCGTGCACCTCCGCGACTCTACTACGGCAAGCT AGTCCGGACGGGTCGTCGTCCCCGCGCGCCACCAGCCCTTGGTGAAACGACAGGGAGCGTCCGGCTTCCC CAGCACCGCCCTGCGAGACTCAAAACAGCCACACCGCAAAGCGAGCCTCGGGCGGAAGGAGGCGGAGCTT CAGGCGGCCCCGCCTCCGCGGAAGGATACACATCTCCGTGGTCCAAAACCCCGGGGCGAGGCGGCCGGGG CGTGTGAGCTGCTCGGCCAGCTGCCGTCTACGCGCTTTCGCGCGGCCACCGGGCAACTGCGCCGCGCGGC TGCCCCGCTGAGCGCTCGGCCTCGGGGCCGTGGGATCCGCCGCGCTGTCTGCGGTCAGGAAGACCGCCCT CCCGCGTCCTTGCCGGACGGGTCAGAGGCGGCACCGCACGCGAGGCCACCCGCGATGCTGCTGTCCAAGT TCGGCTCCCTGGCGCACCTCTGCGGGCCTGGCGGCGTGGACCACCTCCCAGTGAAGATCCTACAGCCAGC CAAGGCTGACAAGGAGAGCTTCGAGAAGGTGTACCAGGTGGGCGCCGTGCTGGGCAGCGGCGGCTTCGGC ACGGTCTACGCGGGCAGCCGCATCGCCGACGGACTCCCGGTGGCTGTGAAGCACGTGGTGAAGGAGCGGG TGACCGAGTGGGGCAGTCTCGGCGGAGTGGCCGTGCCCCTGGAGGTGGTGCTGCTGCGCAAGGTGGGCGC GGCGGGCGGCGCGCGCGGCGTCATCCGCTTGCTGGACTGGTTCGAGCGGCCCGACGGCTTCTTGTTGGTG CTGGAGCGACCCGAGCCGGCACAGGACCTCTTCGACTTCATCACTGAACGAGGCGCCCTGGACGAGCCGC TGGCGCGTCGCTTCTTCGCGCAGGTGCTTGCCGCTGTGCGGCACTGCCACAATTGTGGGGTCGTGCACCG CGACATCAAGGACGAGAACCTGCTGGTGGACCTGCGCTCGGGAGAGCTGAAGCTCATCGACTTCGGCTCG GGCGCGGTGCTCAAGGACACGGTCTACACTGACTTTGATGGCACCCGTGTGTACAGCCCCCCAGAGTGGA TCCGATATCACCGATATCACGGGCGGTCTGCCACTGTGTGGTCTCTGGGTGTACTGCTCTACGACATGGT GTGTGGGGACATTCCCTTTGAGCAGGATGAGGAGATCTTGCGCGGCAGGCTCTTTTTCCGGAGGAGGGTC TCCCCAGAGTGCCAGCAGCTTATTGAGTGGTGTCTCTCCCTGAGGCCCTCAGAGAGGCCCTCCCTGGACC AAATTGCTGCCCACCCCTGGATGCTGGGGACAGAGGGGAGCGTTCCAGAGAACTGTGACCTTCGGCTTTG TGCCCTGGATACTGACGACGGAGCCAGTACCACTTCCAGCAGTGAGAGCTTGTGAGGAGGAGAAGGGGCC TGGGCTCGGCCTAGCCAGCGCTCTCCCAGAATTGAACACTTTCTGCCTGGGATGTCTGCTGCAAAAGCAG TGACCTCTGACCCCTGGTGACCTTTGCTCTCGGCACCGGGCCTGTTTCCTTTGCTTTGAGTGCCTTTTTG AACGCTGCTCCACAGGGCCTGGGTTTTCTTGAGCTCTTCTGTCCAAAGATGGCTGAGGGCTAAGCAAGGT CCTGCCCTGGGTGGATACTTGAACCAGAGATCCCGACCCTGCTGCTCCATCTCAGGAGGCAGCCTTCCTG ACCAAGTGTGTTTGACATGGAGCGCCCTGTGGTGCCCACCTCCAACCCTCCAGTCTCCTGGTGTTCATCT GGGCATGTCTGCACAAGCAATGCAACGCTGGGCCACTGCTGCCCGTCTGCCTCCCCGGCACGGCACGGCT CCGCACGCAACCTAAGCGTGCCACCACGGTCTCTTATTTATGGTGTGATCACCCTGGAGGGCGCCCCCGC CCTGCTGGGGCTATTTATTGTTTAATTTATTTGCTGAGGTTCCTCCAAGCAACCACCTTCTCCAGGCCCC TGGGGTGTTGAAAGTCAAATGTGGCTGTTGAGTCCACAGACCCCCATCCTAATTCCTGCACCTGGAGGAG TTCCCCAACCCCCGTGTTTGCGGGAGGAAGCATTTGTACAGTGGCTAATTTAAGGGGAGTGGGAGACCCT GTCACCCTGAGCACTCTGCGCTGGGGAGGGGTTTAAATTATTGACCTTGTACAGTCTGCTTGCTGGCTCT GAAAGCTGGGGTTGGGGGACAGAGTCTCAAGCCCTTAATTTATTTTAGCAGCTGTGTTTCTGTGACCCTG GTGTGACTAAGCATCAGGGGTGGGGTTGTATAAGTTCAAAAGTGTGAAATGTCTGAAGATCATATTTTTT ATACAGGTATTTCAATTAAATGTTTTGGTATATAATGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_145478
• Insert Size: 981 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC017621, AAH17621
• RefSeq Size: 2447 bp
• RefSeq ORF: 981 bp
• Locus ID: 223775
• UniProt ID: P58750
• Cytogenetics: 15 E3
• Gene Summary: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.[UniProtKB/Swiss-Prot Function]