BCCIP (NM_078469) Human 3' UTR Clone
CAT#: SC214764
3' UTR clone of BRCA2 and CDKN1A interacting protein (BCCIP) transcript variant C for miRNA target validation
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Specifications
Product Data | |
Vector | pMirTarget |
Species | Human |
Transfection Reporter | RFP |
Assay Reporter | Luciferase |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Symbol | BCCIP |
Synonyms | TOK-1; TOK1 |
ACCN | NM_078469 |
Insert Size | 1473 bp |
Sequence Data |
>SC214764 3’UTR clone of NM_078469
The sequence shown below is from the reference sequence of NM_078469. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGTTGGTCTGTTCCCCCAGTATTAGAATAAATTAAAACATACAAGCCAGGATGAATGAAGCCAATAGGA AATAAAAAACAGGCACACAACATTATTTGGGGAAAAACACCTCTAGTGACACATTTTCTTCATCTGCAC TGATTATTTCAGCAAAAGAAATCTAGTATGTTTTCATACATCTGATGTATAAATTTGCTGAACTTTGAG TTAGTTTTCTTAAGATAATTTTTCATATTAAGAAAATTTTCCTTTTCTAACCTATTAAAATACCTCACT ATCATTTCAAAAGGTTAAATGAGTTGATCACTATCTCTGCTCTGTGCTCCTCAAAATATAATTTCAAAT GGATCCGATCTAAATCTATACCTAGTGCAGATTTGCAAAAAAAGAAAAGGAATAGTCATTAAGGATACC TGTTACCATGGCTGCGATTGTTAGCACTTCATCTACACAGTCAAATTCACAGGACGCTAAGATAGACTT CGAGAGTTGTGGATCAAGAGGAAACTCTGACATGATGATTCCAAATTCAGAAAGATTTCCATCATTATC CAGTGCTGCCAGATAATCTAAGTCTTCCAATGCCTGCATCAAACTTTCTGGTGCTAGGAAAGGAAAAAA ATAATAATTTAAGAGTCTCATATGGCTAAGATGGAGAAACAGGTACTGGACTTTTCCCTCCTGCATGAA ACAAGCAAACAATGGACAAAATATGTGAAACAACGGTTTGCAAGCCACCAAATACCAGGGAGTGAAGGA TAGTGATTCTTGAGAGGGCAAACTCAGGAGGGGAGCCCTGTGATTGTCCAGCTCATGCTCCGAGGAGGG TCCCAGCTGCAGTGTGCATGCGGGGGGAACCCAGGTGGAGCCTGCCAGCCTCCCTGCAGTAGGAAAACA ATGCCAGGGATCCAGGGAGACTAAGGTGGCCGGAACTCGCGGTCACAGTACTGGAGAGAGACACACAGA TCTAAGTCGGGGGCCAGAGGGAGCTCCCTCAACTAGGCAGCACAGCCCTACTGATCAGCGCATGTGTGT AAGGAACCACCTCAGGCCAGAGAAAGAGCCATGTGAGAAGATTAGAAGGAACAGTGGTGCTGACACAGG ACCTAGGGTAGGGCCTGTTCCCACCACCCTAGCTGGAAAACCTCATGATTTATGGGGCACTGGGTAGAA AACACAAGTGAGAAACCCTAGATGGGCACTGCCACCTGACACAGCTATACAGCAGGACCTGAAAGGATC ACACTGCATCCTAGGACAAAGCTCAAAAGTACCTCTGGGACTACAAAAATATTCAGTGCCCAAGAAGGT AAAATGTACAATGTCTAGCATCCAGTAGAGAGGCATGAAAAGCAGGAAAATACATTGCATAATACAGAG AAAAATTAATCACAACTGACCTGGATCTCAGATGCTAGAAATAGTAGACAAAGATGTTATTTCCCAGTG CAAATAAAGAAATAAAGATAGCAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. |
Reference Data | |
RefSeq | NM_078469.3 |
Summary | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
Locus ID | 56647 |
MW | 56.6 |
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