XPC Rabbit Polyclonal Antibody
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Other products for "XPC"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB: 1:500~2000 |
Reactivities | Human, Rat, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human XPC |
Formulation | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Concentration | 2.55 mg/ml |
Purification | Purified from the immunized serum by affinity chromatography (Protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 105.8 kDa |
Gene Name | XPC complex subunit, DNA damage recognition and repair factor |
Database Link | |
Background | This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
Synonyms | p125; RAD4; XP3; XPCC |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Nucleotide excision repair |
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