PD-L1 (CD274) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3F5]
CAT#: TA812994AM
CD274 mouse monoclonal antibody,clone OTI3F5, Biotinylated
Conjugation: Unconjugated HRP
Specifications
Product Data | |
Clone Name | OTI3F5 |
Applications | FC, WB |
Recommended Dilution | WB 1:500, FLOW 1:100 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human CD274 (NP_054862) produced in HEK293T cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Biotin |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 33.28 kDa |
Gene Name | CD274 molecule |
Database Link | |
Background | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
Synonyms | B7-H; B7H1; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cell adhesion molecules (CAMs) |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF812994 | Carrier-free (BSA/glycerol-free) CD274 mouse monoclonal antibody,clone OTI3F5 |
USD 600.00 |
|
TA812994 | CD274 mouse monoclonal antibody,clone OTI3F5 |
USD 447.00 |
|
TA812994BM | CD274 mouse monoclonal antibody,clone OTI3F5, HRP conjugated |
USD 509.00 |
|
TA812994S | CD274 mouse monoclonal antibody,clone OTI3F5 |
USD 200.00 |
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