IL12B Mouse Monoclonal Antibody [Clone ID: OTI1A3]
USD 867.00
USD 436.00
Specifications
Product Data | |
Clone Name | OTI1A3 |
Applications | WB |
Recommended Dilution | WB 1:2000 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human IL12B (NP_002178) produced in SF9 cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 34.6 kDa |
Gene Name | interleukin 12B |
Database Link | |
Background | This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008] |
Synonyms | CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2 |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Allograft rejection, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF807426 | Carrier-free (BSA/glycerol-free) IL12B mouse monoclonal antibody, clone OTI1A3 (formerly 1A3) |
USD 600.00 |
|
TA807426 | IL12B mouse monoclonal antibody, clone OTI1A3 (formerly 1A3) |
USD 447.00 |
|
TA807426AM | IL12B mouse monoclonal antibody, clone OTI1A3 (formerly 1A3), Biotinylated |
USD 509.00 |
|
TA807426BM | IL12B mouse monoclonal antibody, clone OTI1A3 (formerly 1A3), HRP conjugated |
USD 509.00 |
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