Macrophage Scavenger Receptor I (MSR1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI7H5]
CAT#: TA802829AM
MSR1 mouse monoclonal antibody,clone 7H5, Biotinylated
Conjugation: Unconjugated HRP
USD 867.00
USD 436.00
Specifications
Product Data | |
Clone Name | OTI7H5 |
Applications | WB |
Recommended Dilution | WB 1:2000 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 197-451 of human MSR1(NP_619730) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Biotin |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 42.8 kDa |
Gene Name | macrophage scavenger receptor 1 |
Database Link | |
Background | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] |
Synonyms | CD204; phSR1; phSR2; SCARA1; SR-A; SRA |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF802829 | Carrier-free (BSA/glycerol-free) MSR1 mouse monoclonal antibody, clone OTI7H5 (formerly 7H5) |
USD 600.00 |
|
TA802829 | MSR1 mouse monoclonal antibody, clone OTI7H5 (formerly 7H5) |
USD 224.00 |
|
TA802829BM | MSR1 mouse monoclonal antibody,clone 7H5, HRP conjugated |
USD 509.00 |
|
TA802829S | MSR1 mouse monoclonal antibody, clone OTI7H5 (formerly 7H5) |
USD 200.00 |
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