MDM2 Mouse Monoclonal Antibody [Clone ID: OTI4B3]
Specifications
Product Data | |
Clone Name | OTI4B3 |
Applications | WB |
Recommended Dilution | WB 1:2000 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 119-438 of human MDM2 (NP_002383)produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 55.8 kDa |
Gene Name | MDM2 proto-oncogene |
Database Link | |
Background | This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008] |
Synonyms | ACTFS; hdm2; HDMX |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Bladder cancer, Cell cycle, Chronic myeloid leukemia, Endocytosis, Glioma, Melanoma, p53 signaling pathway, Pathways in cancer, Prostate cancer, Ubiquitin mediated proteolysis |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF801588 | Carrier-free (BSA/glycerol-free) MDM2 mouse monoclonal antibody, clone OTI4B3 (formerly 4B3) |
USD 600.00 |
|
TA801588 | MDM2 mouse monoclonal antibody, clone OTI4B3 (formerly 4B3) |
USD 447.00 |
|
TA801588AM | MDM2 mouse monoclonal antibody,clone 4B3, Biotinylated |
USD 509.00 |
|
TA801588BM | MDM2 mouse monoclonal antibody,clone 4B3, HRP conjugated |
USD 509.00 |
{0} Product Review(s)
Be the first one to submit a review